3cfd: Difference between revisions

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[[Image:3cfd.jpg|left|200px]]
{{Seed}}
[[Image:3cfd.png|left|200px]]


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{{STRUCTURE_3cfd|  PDB=3cfd  |  SCENE=  }}  
{{STRUCTURE_3cfd|  PDB=3cfd  |  SCENE=  }}  


'''Purple-fluorescent antibody EP2-25C10 in complex with its stilbene hapten'''
===Purple-fluorescent antibody EP2-25C10 in complex with its stilbene hapten===




==Overview==
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The blue-emissive antibody EP2-19G2 that has been elicited against trans-stilbene has unprecedented ability to produce bright luminescence and has been used as a biosensor in various applications. We show that the prolonged luminescence is not stilbene fluorescence. Instead, the emissive species is a charge-transfer excited complex of an anionic stilbene and a cationic, parallel pi-stacked tryptophan. Upon charge recombination, this complex generates exceptionally bright blue light. Complex formation is enabled by a deeply penetrating ligand-binding pocket, which in turn results from a noncanonical interface between the two variable domains of the antibody.
The line below this paragraph, {{ABSTRACT_PUBMED_18309081}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 18309081 is the PubMed ID number.
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{{ABSTRACT_PUBMED_18309081}}


==About this Structure==
==About this Structure==
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[[Category: Immunoglobulin]]
[[Category: Immunoglobulin]]
[[Category: Purple-fluorescent antibody]]
[[Category: Purple-fluorescent antibody]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 21:42:50 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 15:57:26 2008''
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