3eze: Difference between revisions

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[[Image:3eze.jpg|left|200px]]
{{Seed}}
[[Image:3eze.png|left|200px]]


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{{STRUCTURE_3eze|  PDB=3eze  |  SCENE=  }}  
{{STRUCTURE_3eze|  PDB=3eze  |  SCENE=  }}  


'''COMPLEX OF THE AMINO TERMINAL DOMAIN OF ENZYME I AND THE HISTIDINE-CONTAINING PHOSPHOCARRIER PROTEIN HPR FROM ESCHERICHIA COLI NMR, RESTRAINED REGULARIZED MEAN STRUCTURE'''
===COMPLEX OF THE AMINO TERMINAL DOMAIN OF ENZYME I AND THE HISTIDINE-CONTAINING PHOSPHOCARRIER PROTEIN HPR FROM ESCHERICHIA COLI NMR, RESTRAINED REGULARIZED MEAN STRUCTURE===




==Overview==
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The solution structure of the first protein-protein complex of the bacterial phosphoenolpyruvate: sugar phosphotransferase system between the N-terminal domain of enzyme I (EIN) and the histidine-containing phosphocarrier protein HPr has been determined by NMR spectroscopy, including the use of residual dipolar couplings that provide long-range structural information. The complex between EIN and HPr is a classical example of surface complementarity, involving an essentially all helical interface, comprising helices 2, 2', 3 and 4 of the alpha-subdomain of EIN and helices 1 and 2 of HPr, that requires virtually no changes in conformation of the components relative to that in their respective free states. The specificity of the complex is dependent on the correct placement of both van der Waals and electrostatic contacts. The transition state can be formed with minimal changes in overall conformation, and is stabilized in favor of phosphorylated HPr, thereby accounting for the directionality of phosphoryl transfer.
The line below this paragraph, {{ABSTRACT_PUBMED_10048929}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 10048929 is the PubMed ID number.
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{{ABSTRACT_PUBMED_10048929}}


==About this Structure==
==About this Structure==
3EZE is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3EZE OCA].  
3EZE is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3EZE OCA].  


==Reference==
==Reference==
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[[Category: Sugar transport]]
[[Category: Sugar transport]]
[[Category: Transferase]]
[[Category: Transferase]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 22:01:32 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 16:36:41 2008''

Revision as of 13:36, 28 July 2008

File:3eze.png

Template:STRUCTURE 3eze

COMPLEX OF THE AMINO TERMINAL DOMAIN OF ENZYME I AND THE HISTIDINE-CONTAINING PHOSPHOCARRIER PROTEIN HPR FROM ESCHERICHIA COLI NMR, RESTRAINED REGULARIZED MEAN STRUCTURE

Template:ABSTRACT PUBMED 10048929

About this Structure

3EZE is a Protein complex structure of sequences from Escherichia coli. Full experimental information is available from OCA.

Reference

Solution structure of the 40,000 Mr phosphoryl transfer complex between the N-terminal domain of enzyme I and HPr., Garrett DS, Seok YJ, Peterkofsky A, Gronenborn AM, Clore GM, Nat Struct Biol. 1999 Feb;6(2):166-73. PMID:10048929

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