3kvt: Difference between revisions

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[[Image:3kvt.~~jpg~~|left|200px]]

[[Image:3kvt.png|left|200px]]

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~~'''~~TETRAMERIZATION DOMAIN FROM AKV3.1 (SHAW-SUBFAMILY) VOLTAGE-GATED POTASSIUM CHANNEL~~'''~~

===TETRAMERIZATION DOMAIN FROM AKV3.1 (SHAW-SUBFAMILY) VOLTAGE-GATED POTASSIUM CHANNEL===

~~==Overview==~~

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The ~~N-terminal~~, ~~cytoplasmic tetramerization domain~~ (~~T1) of voltage-gated K+ channels encodes molecular determinants for subfamily-specific assembly of alpha-subunits into functional tetrameric channels~~. ~~Crystal structures of T1 tetramers from Shaw and Shaker subfamilies reveal a common four-layered scaffolding~~. ~~Within layer 4, on the hypothetical membrane-facing side of the tetramer~~, ~~the Shaw T1 tetramer contains four zinc ions; each~~ is ~~coordinated by a histidine and two cysteines from one monomer and by one cysteine from an adjacent monomer. The amino acids involved in coordinating~~ the ~~Zn2+ ion occur in a HX5CX20CC sequence motif that is highly conserved among all Shab, Shaw and Shal subfamily members, but is not found in Shaker subfamily members~~. ~~We demonstrate by coimmunoprecipitation that a few characteristic residues in the subunit interface are crucial for subfamily~~-~~specific tetramerization of the T1 domains.~~

The line below this paragraph, {{ABSTRACT_PUBMED_9886290}}, adds the Publication Abstract to the page

(as it appears on PubMed at http://www.pubmed.gov), where 9886290 is the PubMed ID number.

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==About this Structure==

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[[Category: Tetramerization domain]]

[[Category: Zinc-binding]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Sun May~~ ~~4 22~~:05:26 2008''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Jul 3 12:52:20 2008''

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-[[Image:3kvt.jpg|left|200px]]
+{{Seed}}
+[[Image:3kvt.png|left|200px]]
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 {{STRUCTURE_3kvt|  PDB=3kvt  |  SCENE=  }}
-'''TETRAMERIZATION DOMAIN FROM AKV3.1 (SHAW-SUBFAMILY) VOLTAGE-GATED POTASSIUM CHANNEL'''
+===TETRAMERIZATION DOMAIN FROM AKV3.1 (SHAW-SUBFAMILY) VOLTAGE-GATED POTASSIUM CHANNEL===
-==Overview==
+<!--
-The N-terminal, cytoplasmic tetramerization domain (T1) of voltage-gated K+ channels encodes molecular determinants for subfamily-specific assembly of alpha-subunits into functional tetrameric channels. Crystal structures of T1 tetramers from Shaw and Shaker subfamilies reveal a common four-layered scaffolding. Within layer 4, on the hypothetical membrane-facing side of the tetramer, the Shaw T1 tetramer contains four zinc ions; each is coordinated by a histidine and two cysteines from one monomer and by one cysteine from an adjacent monomer. The amino acids involved in coordinating the Zn2+ ion occur in a HX5CX20CC sequence motif that is highly conserved among all Shab, Shaw and Shal subfamily members, but is not found in Shaker subfamily members. We demonstrate by coimmunoprecipitation that a few characteristic residues in the subunit interface are crucial for subfamily-specific tetramerization of the T1 domains.
+The line below this paragraph, {{ABSTRACT_PUBMED_9886290}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 9886290 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_9886290}}
 ==About this Structure==
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 [[Category: Tetramerization domain]]
 [[Category: Zinc-binding]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 22:05:26 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Jul  3 12:52:20 2008''