3ncm: Difference between revisions

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[[Image:3ncm.gif|left|200px]]
{{Seed}}
[[Image:3ncm.png|left|200px]]


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{{STRUCTURE_3ncm|  PDB=3ncm  |  SCENE=  }}  
{{STRUCTURE_3ncm|  PDB=3ncm  |  SCENE=  }}  


'''NEURAL CELL ADHESION MOLECULE, MODULE 2, NMR, 20 STRUCTURES'''
===NEURAL CELL ADHESION MOLECULE, MODULE 2, NMR, 20 STRUCTURES===




==Overview==
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The structure in solution of the second Ig-module fragment of residues 117-208 of NCAM has been determined. Like the first Ig-module of residues 20-116, it belongs to the I set of the immunogloblin superfamily. Module 1 and module 2 interact weakly, and the binding sites of this interaction have been identified. The two-module fragment NCAM(20-208) is a stable dimer. Removal of the charged residues in these sites in NCAM(20-208) abolishes the dimerization. Modeling the dimer of NCAM(20-208) to fit the interactions of these charges produces one coherent binding site for the formation of two antiparallel strands of the first two NCAM modules. This mode of binding could be a major element in trans-cellular interactions in neural cell adhesion.
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{{ABSTRACT_PUBMED_10331878}}


==About this Structure==
==About this Structure==
3NCM is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NCM OCA].  
3NCM is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NCM OCA].  


==Reference==
==Reference==
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[[Category: Immunoglobulin fold]]
[[Category: Immunoglobulin fold]]
[[Category: Neural adhesion molecule]]
[[Category: Neural adhesion molecule]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 22:07:40 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Jul 3 12:57:03 2008''

Revision as of 09:57, 3 July 2008

File:3ncm.png

Template:STRUCTURE 3ncm

NEURAL CELL ADHESION MOLECULE, MODULE 2, NMR, 20 STRUCTURES

Template:ABSTRACT PUBMED 10331878

About this Structure

3NCM is a Single protein structure of sequence from Rattus norvegicus. Full experimental information is available from OCA.

Reference

Structure and interactions of NCAM modules 1 and 2, basic elements in neural cell adhesion., Jensen PH, Soroka V, Thomsen NK, Ralets I, Berezin V, Bock E, Poulsen FM, Nat Struct Biol. 1999 May;6(5):486-93. PMID:10331878

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