3pjr: Difference between revisions

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[[Image:3pjr.gif|left|200px]]
{{Seed}}
[[Image:3pjr.png|left|200px]]


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{{STRUCTURE_3pjr|  PDB=3pjr  |  SCENE=  }}  
{{STRUCTURE_3pjr|  PDB=3pjr  |  SCENE=  }}  


'''HELICASE SUBSTRATE COMPLEX'''
===HELICASE SUBSTRATE COMPLEX===




==Overview==
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We have determined two different structures of PcrA DNA helicase complexed with the same single strand tailed DNA duplex, providing snapshots of different steps on the catalytic pathway. One of the structures is of a complex with a nonhydrolyzable analog of ATP and is thus a "substrate" complex. The other structure contains a bound sulphate ion that sits in a position equivalent to that occupied by the phosphate ion produced after ATP hydrolysis, thereby mimicking a "product" complex. In both complexes, the protein is monomeric. Large and distinct conformational changes occur on binding DNA and the nucleotide cofactor. Taken together, these structures provide evidence against an "active rolling" model for helicase action but are instead consistent with an "inchworm" mechanism.
The line below this paragraph, {{ABSTRACT_PUBMED_10199404}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 10199404 is the PubMed ID number.
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{{ABSTRACT_PUBMED_10199404}}


==About this Structure==
==About this Structure==
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[[Category: Wigley, D B.]]
[[Category: Wigley, D B.]]
[[Category: Helicase]]
[[Category: Helicase]]
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