407d: Difference between revisions

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[[Image:407d.gif|left|200px]]
{{Seed}}
[[Image:407d.png|left|200px]]


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{{STRUCTURE_407d|  PDB=407d  |  SCENE=  }}  
{{STRUCTURE_407d|  PDB=407d  |  SCENE=  }}  


'''STRUCTURAL BASIS FOR RECOGNITION OF A-T AND T-A BASE PAIRS IN THE MINOR GROOVE OF B-DNA'''
===STRUCTURAL BASIS FOR RECOGNITION OF A-T AND T-A BASE PAIRS IN THE MINOR GROOVE OF B-DNA===




==Overview==
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Polyamide dimers containing three types of aromatic rings-pyrrole, imidazole, and hydroxypyrrole-afford a small-molecule recognition code that discriminates among all four Watson-Crick base pairs in the minor groove. The crystal structure of a specific polyamide dimer-DNA complex establishes the structural basis for distinguishing T.A from A.T base pairs. Specificity for the T.A base pair is achieved by means of distinct hydrogen bonds between pairs of substituted pyrroles on the ligand and the O2 of thymine and N3 of adenine. In addition, shape-selective recognition of an asymmetric cleft between the thymine-O2 and the adenine-C2 was observed. Although hitherto similarities among the base pairs in the minor groove have been emphasized, the structure illustrates differences that allow specific minor groove recognition.
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{{ABSTRACT_PUBMED_9756473}}


==About this Structure==
==About this Structure==
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[[Category: Rees]]
[[Category: Rees]]
[[Category: Drugs in the dna minor groove]]
[[Category: Drugs in the dna minor groove]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 22:16:20 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Jul 3 13:15:23 2008''

Revision as of 10:15, 3 July 2008

File:407d.png

Template:STRUCTURE 407d

STRUCTURAL BASIS FOR RECOGNITION OF A-T AND T-A BASE PAIRS IN THE MINOR GROOVE OF B-DNA

Template:ABSTRACT PUBMED 9756473

About this Structure

Full crystallographic information is available from OCA.

Reference

A structural basis for recognition of A.T and T.A base pairs in the minor groove of B-DNA., Kielkopf CL, White S, Szewczyk JW, Turner JM, Baird EE, Dervan PB, Rees DC, Science. 1998 Oct 2;282(5386):111-5. PMID:9756473

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