417d: Difference between revisions

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[[Image:417d.gif|left|200px]]
{{Seed}}
[[Image:417d.png|left|200px]]


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{{STRUCTURE_417d|  PDB=417d  |  SCENE=  }}  
{{STRUCTURE_417d|  PDB=417d  |  SCENE=  }}  


'''A THYMINE-LIKE BASE ANALOGUE FORMS WOBBLE PAIRS WITH ADENINE'''
===A THYMINE-LIKE BASE ANALOGUE FORMS WOBBLE PAIRS WITH ADENINE===




==Overview==
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The DNA hexamer d(CACGPG), in which dP is the ambivalent pyrimidine nucleoside analogue 2'-deoxy-beta-d-ribofuranosyl-(6H,8H-3, 4-dihydropyrimido[4,5-c][1,2]oxazin-7-one), crystallises as a left-handed Z-DNA duplex. X-ray analysis at 1.5 A shows that both P. A base-pairs are of the wobble type. This result appears inconsistent with other evidence from hybridisation and NMR studies of P-containing oligonucleotides, which suggests that, while P can form stable base-pairs with either A or G, thymine-like properties are more pronounced. Thermal denaturation experiments over a range of solution pH values indicate that protonation of the P.A base-pairs is unlikely to be responsible for the anomalous behaviour. No specific crystal packing effects can be identfied as an explanation, and it is concluded that base stacking and other interactions between nucleotide residues in Z-DNA are responsible.
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{{ABSTRACT_PUBMED_9753550}}


==About this Structure==
==About this Structure==
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[[Category: Pyrimidine analogue]]
[[Category: Pyrimidine analogue]]
[[Category: Z-dna]]
[[Category: Z-dna]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 22:16:46 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Jul 3 13:16:29 2008''

Revision as of 10:16, 3 July 2008

File:417d.png

Template:STRUCTURE 417d

A THYMINE-LIKE BASE ANALOGUE FORMS WOBBLE PAIRS WITH ADENINE

Template:ABSTRACT PUBMED 9753550

About this Structure

Full crystallographic information is available from OCA.

Reference

A thymine-like base analogue forms wobble pairs with adenine in a Z-DNA duplex., Schuerman GS, Van Meervelt L, Loakes D, Brown DM, Kong Thoo Lin P, Moore MH, Salisbury SA, J Mol Biol. 1998 Oct 9;282(5):1005-11. PMID:9753550

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