463d: Difference between revisions

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[[Image:463d.gif|left|200px]]
{{Seed}}
[[Image:463d.png|left|200px]]


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{{STRUCTURE_463d|  PDB=463d  |  SCENE=  }}  
{{STRUCTURE_463d|  PDB=463d  |  SCENE=  }}  


'''CALCIUM FORM OF D(CGCGAATTCGCG)2'''
===CALCIUM FORM OF D(CGCGAATTCGCG)2===




==Overview==
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The dodecamer d(CGCGAATTCGCG) was the first oligonucleotide to be crystallized as a B-DNA duplex. Its structure was analyzed in detail in the early 1980s. Here we show that, in the presence of Ca(2+), it crystallizes in a different way (R3 space group). The dodecamers form parallel columns of straight duplexes with ten base pairs in the B form. The terminal cytosines in each molecule are disordered, whereas the terminal guanines are placed in the minor groove of neighbor duplexes. The central GAATTC region is practically identical to that found in the classic structure of the same dodecamer crystallized in the P2(1)2(1)2(1) space group in the presence of Mg(2+) and spermine. Its structure is thus independent of the crystallization conditions which have been used.
The line below this paragraph, {{ABSTRACT_PUBMED_10455145}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 10455145 is the PubMed ID number.
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{{ABSTRACT_PUBMED_10455145}}


==About this Structure==
==About this Structure==
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[[Category: Ca2+ binding]]
[[Category: Ca2+ binding]]
[[Category: Dickerson-drew dodecamer]]
[[Category: Dickerson-drew dodecamer]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 22:19:08 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Jul 3 13:23:19 2008''

Revision as of 10:23, 3 July 2008

File:463d.png

Template:STRUCTURE 463d

CALCIUM FORM OF D(CGCGAATTCGCG)2

Template:ABSTRACT PUBMED 10455145

About this Structure

Full crystallographic information is available from OCA.

Reference

Structure of d(CGCGAATTCGCG) in the presence of Ca(2+) ions., Liu J, Subirana JA, J Biol Chem. 1999 Aug 27;274(35):24749-52. PMID:10455145

Page seeded by OCA on Thu Jul 3 13:23:19 2008

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