469d: Difference between revisions

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[[Image:469d.gif|left|200px]]
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{{STRUCTURE_469d|  PDB=469d  |  SCENE=  }}  
{{STRUCTURE_469d|  PDB=469d  |  SCENE=  }}  


'''CRYSTAL STRUCTURE AND IMPROVED ANTISENSE PROPERTIES OF 2'-O-(2-METHOXYETHYL)-RNA'''
===CRYSTAL STRUCTURE AND IMPROVED ANTISENSE PROPERTIES OF 2'-O-(2-METHOXYETHYL)-RNA===




==Overview==
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2'-O-(2-Methoxyethyl)-RNA (MOE-RNA) is a nucleic acid analog with promising features for antisense applications. Compared with phosphorothioate DNA (PS-DNA), the MOE modification offers improved nuclease resistance, enhanced RNA affinity, improved cellular uptake and intestinal absorption, reduced toxicity and immune stimulation. The crystal structure of a fully modified MOE-RNA dodecamer duplex (CGCGAAUUCGCG) was determined at 1.7 A resolution. In the majority of the MOE substituents, the torsion angle around the ethylene alkyl chain assumes a gauche conformation. The conformational preorganization of the MOE groups is consistent with the improved RNA affinity and the extensive hydration of the substituents could play a role in the improved cellular uptake of MOE-RNA. A specific hydration pattern that bridges substituent and phosphate oxygen atoms in the minor groove of MOE-RNA may explain its high nuclease resistance.
The line below this paragraph, {{ABSTRACT_PUBMED_10360355}}, adds the Publication Abstract to the page
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{{ABSTRACT_PUBMED_10360355}}


==About this Structure==
==About this Structure==
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[[Category: Tereshko, V.]]
[[Category: Tereshko, V.]]
[[Category: Rna dodecamer duplex]]
[[Category: Rna dodecamer duplex]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 22:19:22 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Jul 3 13:24:15 2008''

Revision as of 10:24, 3 July 2008

File:469d.png

Template:STRUCTURE 469d

CRYSTAL STRUCTURE AND IMPROVED ANTISENSE PROPERTIES OF 2'-O-(2-METHOXYETHYL)-RNA

Template:ABSTRACT PUBMED 10360355

About this Structure

Full crystallographic information is available from OCA.

Reference

Crystal structure and improved antisense properties of 2'-O-(2-methoxyethyl)-RNA., Teplova M, Minasov G, Tereshko V, Inamati GB, Cook PD, Manoharan M, Egli M, Nat Struct Biol. 1999 Jun;6(6):535-9. PMID:10360355

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