4aig: Difference between revisions

From Proteopedia
Jump to navigationJump to search
← Older editNewer edit →
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,328,572 edits
No edit summary
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,328,572 edits
No edit summary
Line 1: Line 1:
[[Image:4aig.gif|left|200px]]
{{Seed}}
[[Image:4aig.png|left|200px]]


<!--
<!--
Line 9: Line 10:
{{STRUCTURE_4aig|  PDB=4aig  |  SCENE=  }}  
{{STRUCTURE_4aig|  PDB=4aig  |  SCENE=  }}  


'''ADAMALYSIN II WITH PHOSPHONATE INHIBITOR'''
===ADAMALYSIN II WITH PHOSPHONATE INHIBITOR===




==Overview==
<!--
The search of reprolysin inhibitors offers the possibility of intervention against both matrixins and ADAMs. Here we report the crystal structure of the complex between adamalysin II, a member of the reprolysin family, and a phosphonate inhibitor modeled on an endogenous venom tripeptide. The inhibitor occupies the primed region of the cleavage site adopting a retro-binding mode. The phosphonate group ligates the zinc ion in an asymmetric bidentate mode and the adjacent Trp indole system partly fills the primary specificity subsite S1'. An adamalysin-based model of tumor necrosis factor-alpha-converting enzyme (TACE) reveals a smaller S1' pocket for this enzyme.
The line below this paragraph, {{ABSTRACT_PUBMED_9428736}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 9428736 is the PubMed ID number.
-->
{{ABSTRACT_PUBMED_9428736}}


==About this Structure==
==About this Structure==
Line 29: Line 33:
[[Category: Snake venom metalloendopeptidase]]
[[Category: Snake venom metalloendopeptidase]]
[[Category: Zinc protease]]
[[Category: Zinc protease]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 22:20:29 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Jul 3 13:27:24 2008''
Retrieved from "https://proteopedia.org/4aig"