4gst: Difference between revisions

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[[Image:4gst.~~jpg~~|left|200px]]

[[Image:4gst.png|left|200px]]

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~~'''~~REACTION COORDINATE MOTION IN AN SNAR REACTION CATALYZED BY GLUTATHIONE TRANSFERASE~~'''~~

===REACTION COORDINATE MOTION IN AN SNAR REACTION CATALYZED BY GLUTATHIONE TRANSFERASE===

~~==Overview==~~

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The ~~three-dimensional structures of a class mu glutathione transferase in complex with a transition-state analogue~~, ~~1-(S-glutathionyl)-2~~,~~4,6-trinitrocyclohexadienate, and a product, 1-(S-glutathionyl)-2,4-dinitrobenzene, of a nucleophilic aromatic substitution~~ (~~SNAr) reaction have been determined~~ at 1.~~9- and 2~~.~~0-A resolution~~, ~~respectively~~. ~~The two structures represent snapshots along the reaction coordinate for the enzyme~~-~~catalyzed reaction of glutathione with 1~~-chloro-2,4-dinitrobenzene and reveal specific interactions between the enzyme, intermediate, and product that are important in catalysis. The geometries of the intermediate and product are used to postulate reaction coordinate motion during catalysis.

The line below this paragraph, {{ABSTRACT_PUBMED_8241147}}, adds the Publication Abstract to the page

(as it appears on PubMed at http://www.pubmed.gov), where 8241147 is the PubMed ID number.

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==About this Structure==

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[[Category: Ji, X.]]

[[Category: Glutathione transferase]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Sun May~~ ~~4 22~~:24:55 2008''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Jul 3 13:39:54 2008''

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-[[Image:4gst.jpg|left|200px]]
+{{Seed}}
+[[Image:4gst.png|left|200px]]
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 {{STRUCTURE_4gst|  PDB=4gst  |  SCENE=  }}
-'''REACTION COORDINATE MOTION IN AN SNAR REACTION CATALYZED BY GLUTATHIONE TRANSFERASE'''
+===REACTION COORDINATE MOTION IN AN SNAR REACTION CATALYZED BY GLUTATHIONE TRANSFERASE===
-==Overview==
+<!--
-The three-dimensional structures of a class mu glutathione transferase in complex with a transition-state analogue, 1-(S-glutathionyl)-2,4,6-trinitrocyclohexadienate, and a product, 1-(S-glutathionyl)-2,4-dinitrobenzene, of a nucleophilic aromatic substitution (SNAr) reaction have been determined at 1.9- and 2.0-A resolution, respectively. The two structures represent snapshots along the reaction coordinate for the enzyme-catalyzed reaction of glutathione with 1-chloro-2,4-dinitrobenzene and reveal specific interactions between the enzyme, intermediate, and product that are important in catalysis. The geometries of the intermediate and product are used to postulate reaction coordinate motion during catalysis.
+The line below this paragraph, {{ABSTRACT_PUBMED_8241147}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 8241147 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_8241147}}
 ==About this Structure==
@@ Line 27: / Line 31: @@
 [[Category: Ji, X.]]
 [[Category: Glutathione transferase]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 22:24:55 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Jul  3 13:39:54 2008''