4tss: Difference between revisions

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[[Image:4tss.gif|left|200px]]
{{Seed}}
[[Image:4tss.png|left|200px]]


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{{STRUCTURE_4tss|  PDB=4tss  |  SCENE=  }}  
{{STRUCTURE_4tss|  PDB=4tss  |  SCENE=  }}  


'''TOXIC SHOCK SYNDROME TOXIN-1: TETRAGONAL P4(1)2(1)2 CRYSTAL FORM'''
===TOXIC SHOCK SYNDROME TOXIN-1: TETRAGONAL P4(1)2(1)2 CRYSTAL FORM===




==Overview==
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The structure of toxic shock syndrome toxin-1 (TSST-1), the causative agent in toxic shock syndrome, has been determined in three crystal forms. The three structural models have been refined to R-factors of 0.154, 0.150, and 0.198 at resolutions of 2.05 A, 2.90 A, and 2.75 A, respectively. One crystal form of TSST-1 contains a zinc ion bound between two symmetry-related molecules. Although not required for biological activity, zinc dramatically potentiates the mitogenicity of TSST-1 at very low concentrations. In addition, the structure of the tetramutant TSST-1H [T69I, Y80W, E132K, I140T], which is nonmitogenic and does not amplify endotoxin shock, has been determined and refined in a fourth crystal form (R-factor = 0.173 to 1.9 A resolution).
The line below this paragraph, {{ABSTRACT_PUBMED_9194182}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 9194182 is the PubMed ID number.
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{{ABSTRACT_PUBMED_9194182}}


==About this Structure==
==About this Structure==
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[[Category: Superantigen]]
[[Category: Superantigen]]
[[Category: Toxin]]
[[Category: Toxin]]
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