4ubp: Difference between revisions

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[[Image:4ubp.~~gif~~|left|200px]]

[[Image:4ubp.png|left|200px]]

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~~'''~~STRUCTURE OF BACILLUS PASTEURII UREASE INHIBITED WITH ACETOHYDROXAMIC ACID AT 1.55 A RESOLUTION~~'''~~

===STRUCTURE OF BACILLUS PASTEURII UREASE INHIBITED WITH ACETOHYDROXAMIC ACID AT 1.55 A RESOLUTION===

~~==Overview==~~

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The ~~structure of Bacillus pasteurii urease inhibited with acetohydroxamic acid was solved and refined anisotropically using synchrotron X-ray cryogenic diffraction data (1.55 A resolution~~, ~~99.5% completeness~~, ~~data redundancy = 26, R-factor = 15.1%, PDB code 4UBP). The two Ni ions in~~ the ~~active site are separated by a distance of 3~~.~~53 A~~. ~~The structure clearly shows the binding mode of the inhibitor anion~~, ~~symmetrically bridging the two Ni ions in the active site through the hydroxamate oxygen and chelating one Ni ion through the carbonyl oxygen. The flexible flap flanking the active site cavity~~ is in the ~~open conformation~~. ~~The possible implications of the results on structure~~-~~based molecular design of new urease inhibitors are discussed.~~

The line below this paragraph, {{ABSTRACT_PUBMED_10766443}}, adds the Publication Abstract to the page

(as it appears on PubMed at http://www.pubmed.gov), where 10766443 is the PubMed ID number.

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==About this Structure==

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[[Category: Nickel]]

[[Category: Urease]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Sun May~~ ~~4 22~~:30:50 2008''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Jul 3 13:53:48 2008''

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-[[Image:4ubp.gif|left|200px]]
+{{Seed}}
+[[Image:4ubp.png|left|200px]]
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 {{STRUCTURE_4ubp|  PDB=4ubp  |  SCENE=  }}
-'''STRUCTURE OF BACILLUS PASTEURII UREASE INHIBITED WITH ACETOHYDROXAMIC ACID AT 1.55 A RESOLUTION'''
+===STRUCTURE OF BACILLUS PASTEURII UREASE INHIBITED WITH ACETOHYDROXAMIC ACID AT 1.55 A RESOLUTION===
-==Overview==
+<!--
-The structure of Bacillus pasteurii urease inhibited with acetohydroxamic acid was solved and refined anisotropically using synchrotron X-ray cryogenic diffraction data (1.55 A resolution, 99.5% completeness, data redundancy = 26, R-factor = 15.1%, PDB code 4UBP). The two Ni ions in the active site are separated by a distance of 3.53 A. The structure clearly shows the binding mode of the inhibitor anion, symmetrically bridging the two Ni ions in the active site through the hydroxamate oxygen and chelating one Ni ion through the carbonyl oxygen. The flexible flap flanking the active site cavity is in the open conformation. The possible implications of the results on structure-based molecular design of new urease inhibitors are discussed.
+The line below this paragraph, {{ABSTRACT_PUBMED_10766443}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 10766443 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_10766443}}
 ==About this Structure==
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 [[Category: Nickel]]
 [[Category: Urease]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 22:30:50 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Jul  3 13:53:48 2008''