4vub: Difference between revisions

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[[Image:4vub.gif|left|200px]]
{{Seed}}
[[Image:4vub.png|left|200px]]


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{{STRUCTURE_4vub|  PDB=4vub  |  SCENE=  }}  
{{STRUCTURE_4vub|  PDB=4vub  |  SCENE=  }}  


'''CCDB, A TOPOISOMERASE POISON FROM ESCHERICHIA COLI'''
===CCDB, A TOPOISOMERASE POISON FROM ESCHERICHIA COLI===




==Overview==
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The crystal structure of CcdB, a protein that poisons Escherichia coli gyrase, was determined in three crystal forms. The protein consists of a five-stranded antiparallel beta-pleated sheet followed by a C-terminal alpha-helix. In one of the loops of the sheet, a second small three-stranded antiparallel beta-sheet is inserted that sticks out of the molecule as a wing. This wing contains the LysC proteolytic cleavage site that is protected by CcdA and, therefore, forms a likely CcdA recognition site. A dimer is formed by sheet extension and by extensive hydrophobic contacts involving three of the five methionine residues and the C terminus of the alpha-helix. The surface of the dimer on the side of the alpha-helix is overall negatively charged, while the opposite side as well as the wing sheet is dominated by positive charges. We propose that the CcdB dimer binds into the central hole of the 59 kDa N-terminal fragment of GyrA, after disruption of the head dimer interface of GyrA.
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{{ABSTRACT_PUBMED_9917404}}


==About this Structure==
==About this Structure==
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[[Category: Plasmid addiction]]
[[Category: Plasmid addiction]]
[[Category: Topoisomerase poison]]
[[Category: Topoisomerase poison]]
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Revision as of 10:54, 3 July 2008

File:4vub.png

Template:STRUCTURE 4vub

CCDB, A TOPOISOMERASE POISON FROM ESCHERICHIA COLI

Template:ABSTRACT PUBMED 9917404

About this Structure

4VUB is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.

Reference

Crystal structure of CcdB, a topoisomerase poison from E. coli., Loris R, Dao-Thi MH, Bahassi EM, Van Melderen L, Poortmans F, Liddington R, Couturier M, Wyns L, J Mol Biol. 1999 Jan 29;285(4):1667-77. PMID:9917404

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