5ktq: Difference between revisions

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[[Image:5ktq.gif|left|200px]]
{{Seed}}
[[Image:5ktq.png|left|200px]]


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{{STRUCTURE_5ktq|  PDB=5ktq  |  SCENE=  }}  
{{STRUCTURE_5ktq|  PDB=5ktq  |  SCENE=  }}  


'''LARGE FRAGMENT OF TAQ DNA POLYMERASE BOUND TO DCTP'''
===LARGE FRAGMENT OF TAQ DNA POLYMERASE BOUND TO DCTP===




==Overview==
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The crystal structures of the Klenow fragment of the Thermus aquaticus DNA polymerase I (Klentaq1) complexed with four deoxyribonucleoside triphosphates (dNTP) have been determined to 2.5 A resolution. The dNTPs bind adjacent to the O helix of Klentaq1. The triphosphate moieties are at nearly identical positions in all four complexes and are anchored by three positively charged residues, Arg659, Lys663, and Arg587, and by two polar residues, His639 and Gln613. The configuration of the base moieties in the Klentaq1/dNTP complexes demonstrates variability suggesting that dNTP binding is primarily determined by recognition and binding of the phosphate moiety. However, when superimposed on the Taq polymerase/blunt end DNA complex structure (Eom et al., 1996), two of the dNTP/Klentaq1 structures demonstrate appropriate stacking of the nucleotide base with the 3' end of the DNA primer strand, suggesting that at least in these two binary complexes, the observed dNTP conformations are functionally relevant.
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{{ABSTRACT_PUBMED_9605316}}


==About this Structure==
==About this Structure==
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[[Category: Waksman, G.]]
[[Category: Waksman, G.]]
[[Category: Large fragement of taq dna polymerase i]]
[[Category: Large fragement of taq dna polymerase i]]
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Revision as of 11:05, 3 July 2008

File:5ktq.png

Template:STRUCTURE 5ktq

LARGE FRAGMENT OF TAQ DNA POLYMERASE BOUND TO DCTP

Template:ABSTRACT PUBMED 9605316

About this Structure

5KTQ is a Single protein structure of sequence from Thermus aquaticus. Full crystallographic information is available from OCA.

Reference

Crystal structures of the Klenow fragment of Thermus aquaticus DNA polymerase I complexed with deoxyribonucleoside triphosphates., Li Y, Kong Y, Korolev S, Waksman G, Protein Sci. 1998 May;7(5):1116-23. PMID:9605316

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