5p2p: Difference between revisions

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[[Image:5p2p.gif|left|200px]]
{{Seed}}
[[Image:5p2p.png|left|200px]]


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{{STRUCTURE_5p2p|  PDB=5p2p  |  SCENE=  }}  
{{STRUCTURE_5p2p|  PDB=5p2p  |  SCENE=  }}  


'''X-RAY STRUCTURE OF PHOSPHOLIPASE A2 COMPLEXED WITH A SUBSTRATE-DERIVED INHIBITOR'''
===X-RAY STRUCTURE OF PHOSPHOLIPASE A2 COMPLEXED WITH A SUBSTRATE-DERIVED INHIBITOR===




==Overview==
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Phospholipases A2 play a part in a number of physiologically important cellular processes such as inflammation, blood platelet aggregation and acute hypersensitivity. These processes are all initiated by the release of arachidonic acid from cell membranes which is catalysed by intracellular phospholipases A2 and followed by conversion of arachidonic acid to prostaglandins, leukotrienes or thromboxanes. An imbalance in the production of these compounds can lead to chronic inflammatory diseases such as rheumatoid arthritis and asthma. Inhibitors of phospholipase A2 might therefore act to reduce the effects of inflammation, so structural information about the binding of phospholipase A2 to its substrates could be helpful in the design of therapeutic drugs. The three-dimensional structure is not known for any intracellular phospholipase A2, but these enzymes share significant sequence homology with secreted phospholipases, for which some of the structures have been determined. Here we report the structure of a complex between an extracellular phospholipase A2 and a competitively inhibiting substrate analogue, which reveals considerable detail about the interaction and suggests a mechanism for catalysis by this enzyme.
The line below this paragraph, {{ABSTRACT_PUBMED_2215698}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 2215698 is the PubMed ID number.
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{{ABSTRACT_PUBMED_2215698}}


==About this Structure==
==About this Structure==
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[[Category: Kalk, K H.]]
[[Category: Kalk, K H.]]
[[Category: Thunnissen, M M.G M.]]
[[Category: Thunnissen, M M.G M.]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 22:36:34 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Jul 3 14:07:53 2008''

Revision as of 11:07, 3 July 2008

File:5p2p.png

Template:STRUCTURE 5p2p

X-RAY STRUCTURE OF PHOSPHOLIPASE A2 COMPLEXED WITH A SUBSTRATE-DERIVED INHIBITOR

Template:ABSTRACT PUBMED 2215698

About this Structure

5P2P is a Single protein structure of sequence from Sus scrofa. Full crystallographic information is available from OCA.

Reference

X-ray structure of phospholipase A2 complexed with a substrate-derived inhibitor., Thunnissen MM, Ab E, Kalk KH, Drenth J, Dijkstra BW, Kuipers OP, Dijkman R, de Haas GH, Verheij HM, Nature. 1990 Oct 18;347(6294):689-91. PMID:2215698

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