6cgt: Difference between revisions

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[[Image:6cgt.gif|left|200px]]
{{Seed}}
[[Image:6cgt.png|left|200px]]


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{{STRUCTURE_6cgt|  PDB=6cgt  |  SCENE=  }}  
{{STRUCTURE_6cgt|  PDB=6cgt  |  SCENE=  }}  


'''HOXA COMPLEX OF CYCLODEXTRIN GLYCOSYLTRANSFERASE MUTANT'''
===HOXA COMPLEX OF CYCLODEXTRIN GLYCOSYLTRANSFERASE MUTANT===




==Overview==
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Bacterial cyclodextrin glycosyltransferases use starch to produce cyclic maltooligosaccharides (cyclodextrins) which are of interest in various applications. The cyclization reaction gives rise to a spectrum of ring sizes consisting of predominantly six to eight glucosyl units. Using the enzyme from Bacillus circulans strain no. 8, binding studies have been performed with several substrates and analogues. The observed binding modes differ in detail, but agree in general with data on homologous enzymes. Based on these binding studies, two mutations were designed that changed the production spectrum from the predominant product beta-cyclodextrin of the wild-type enzyme towards gamma-cyclodextrin, which is of practical interest because it is rare and can encapsulate larger nonpolar compounds.
The line below this paragraph, {{ABSTRACT_PUBMED_9738912}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 9738912 is the PubMed ID number.
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{{ABSTRACT_PUBMED_9738912}}


==About this Structure==
==About this Structure==
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[[Category: Glycosyltransferase]]
[[Category: Glycosyltransferase]]
[[Category: Starch degradation]]
[[Category: Starch degradation]]
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