7cat: Difference between revisions

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~~'''~~THE NADPH BINDING SITE ON BEEF LIVER CATALASE~~'''~~

===THE NADPH BINDING SITE ON BEEF LIVER CATALASE===

~~==Overview==~~

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~~Beef liver and human erythrocyte catalases (EC 1.11.1.6) bind NADP tenaciously [Kirkman~~, ~~H. N. & Gaetani~~, ~~G. F. (1984) Proc. Natl. Acad. Sci. USA 81, 4343-4348]. The position of NADP on beef liver catalase corresponds to~~ the ~~carboxyl-terminal polypeptide hinge in Penicillium vitale fungal catalase, which connects the common catalase structure~~ to the ~~additional flavodoxin-like domain~~. In contrast to nearly all other known structures of protein-bound NADP, NAD, and FAD, the NADP molecule of beef liver catalase is folded into a right-handed helix and bound, in part, in the vicinity of the carboxyl end of two alpha-helices. ~~A water molecule (W7~~) ~~occupies a pseudosubstrate site close to the C4 position of the nicotinamide and is hydrogen bonded to His-304. Although the NADP and heme groups approach each other to within 13.7 A~~, ~~there~~ is ~~no direct interaction. The function of~~ the ~~NADP remains a mystery~~.

The line below this paragraph, {{ABSTRACT_PUBMED_3856839}}, adds the Publication Abstract to the page

(as it appears on PubMed at http://www.pubmed.gov), where 3856839 is the PubMed ID number.

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==About this Structure==

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[[Category: Sicignano, A.]]

[[Category: Tanaka, N.]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Sun May~~ ~~4 22~~:44:11 2008''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Jul 3 14:30:38 2008''

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-[[Image:7cat.gif|left|200px]]
+{{Seed}}
+[[Image:7cat.png|left|200px]]
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 {{STRUCTURE_7cat|  PDB=7cat  |  SCENE=  }}
-'''THE NADPH BINDING SITE ON BEEF LIVER CATALASE'''
+===THE NADPH BINDING SITE ON BEEF LIVER CATALASE===
-==Overview==
+<!--
-Beef liver and human erythrocyte catalases (EC 1.11.1.6) bind NADP tenaciously [Kirkman, H. N. &amp; Gaetani, G. F. (1984) Proc. Natl. Acad. Sci. USA 81, 4343-4348]. The position of NADP on beef liver catalase corresponds to the carboxyl-terminal polypeptide hinge in Penicillium vitale fungal catalase, which connects the common catalase structure to the additional flavodoxin-like domain. In contrast to nearly all other known structures of protein-bound NADP, NAD, and FAD, the NADP molecule of beef liver catalase is folded into a right-handed helix and bound, in part, in the vicinity of the carboxyl end of two alpha-helices. A water molecule (W7) occupies a pseudosubstrate site close to the C4 position of the nicotinamide and is hydrogen bonded to His-304. Although the NADP and heme groups approach each other to within 13.7 A, there is no direct interaction. The function of the NADP remains a mystery.
+The line below this paragraph, {{ABSTRACT_PUBMED_3856839}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 3856839 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_3856839}}
 ==About this Structure==
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 [[Category: Sicignano, A.]]
 [[Category: Tanaka, N.]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 22:44:11 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Jul  3 14:30:38 2008''