8drh: Difference between revisions

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[[Image:8drh.~~jpg~~|left|200px]]

[[Image:8drh.png|left|200px]]

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~~'''~~HIGH RESOLUTION NMR STRUCTURE OF THE D(GCGTCAGG)R(CCUGACGC) HYBRID, MINIMIZED AVERAGE STRUCTURE~~'''~~

===HIGH RESOLUTION NMR STRUCTURE OF THE D(GCGTCAGG)R(CCUGACGC) HYBRID, MINIMIZED AVERAGE STRUCTURE===

~~==Overview==~~

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In this ~~work~~, ~~we present~~ the ~~first NMR solution structure of a DNA~~/~~RNA hybrid containing stereoregular Rp-phosphorothioate modifications of all DNA backbone linkages~~. ~~The complex of the enzymatically synthesized phosphorothioate DNA octamer (all-Rp~~)~~-d(GCGTCAGG) and its complementary RNA r(CCUGACGC) was found to adopt an overall conformation within~~ the ~~A-form family~~. ~~Most helical parameters and the sugar puckers of the DNA strand assume values intermediate between A~~- ~~and B~~-form. The close structural similarity with the unmodified DNA/RNA hybrid of the same sequence may explain why both the natural and the sulfur-substituted complex can be recognized and digested by ribonuclease H.

The line below this paragraph, {{ABSTRACT_PUBMED_9546216}}, adds the Publication Abstract to the page

(as it appears on PubMed at http://www.pubmed.gov), where 9546216 is the PubMed ID number.

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==About this Structure==

Full ~~crystallographic~~ information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8DRH OCA].

Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8DRH OCA].

==Reference==

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[[Category: Dna/rna hybrid]]

[[Category: Oligonucleotide]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Sun May 4 22~~:49:12 2008''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri Jul 11 12:56:17 2008''

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-[[Image:8drh.jpg|left|200px]]
+{{Seed}}
+[[Image:8drh.png|left|200px]]
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@@ Line 9: / Line 10: @@
 {{STRUCTURE_8drh|  PDB=8drh  |  SCENE=  }}
-'''HIGH RESOLUTION NMR STRUCTURE OF THE D(GCGTCAGG)R(CCUGACGC) HYBRID, MINIMIZED AVERAGE STRUCTURE'''
+===HIGH RESOLUTION NMR STRUCTURE OF THE D(GCGTCAGG)R(CCUGACGC) HYBRID, MINIMIZED AVERAGE STRUCTURE===
-==Overview==
+<!--
-In this work, we present the first NMR solution structure of a DNA/RNA hybrid containing stereoregular Rp-phosphorothioate modifications of all DNA backbone linkages. The complex of the enzymatically synthesized phosphorothioate DNA octamer (all-Rp)-d(GCGTCAGG) and its complementary RNA r(CCUGACGC) was found to adopt an overall conformation within the A-form family. Most helical parameters and the sugar puckers of the DNA strand assume values intermediate between A- and B-form. The close structural similarity with the unmodified DNA/RNA hybrid of the same sequence may explain why both the natural and the sulfur-substituted complex can be recognized and digested by ribonuclease H.
+The line below this paragraph, {{ABSTRACT_PUBMED_9546216}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 9546216 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_9546216}}
 ==About this Structure==
-Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8DRH OCA].
+Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8DRH OCA].
 ==Reference==
@@ Line 29: / Line 33: @@
 [[Category: Dna/rna hybrid]]
 [[Category: Oligonucleotide]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 22:49:12 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri Jul 11 12:56:17 2008''