8psh: Difference between revisions

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[[Image:8psh.gif|left|200px]]
{{Seed}}
[[Image:8psh.png|left|200px]]


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{{STRUCTURE_8psh|  PDB=8psh  |  SCENE=  }}  
{{STRUCTURE_8psh|  PDB=8psh  |  SCENE=  }}  


'''HIGH RESOLUTION NMR STRUCTURE OF THE STEREOREGULAR (ALL-RP)-PHOSPHOROTHIOATE-DNA/RNA HYBRID D (G*PS*C*PS*G*PS*T*PS*C*PS*A*PS*G*PS*G)R(CCUGACGC), MINIMIZED AVERAGE STRUCTURE'''
===HIGH RESOLUTION NMR STRUCTURE OF THE STEREOREGULAR (ALL-RP)-PHOSPHOROTHIOATE-DNA/RNA HYBRID D (G*PS*C*PS*G*PS*T*PS*C*PS*A*PS*G*PS*G)R(CCUGACGC), MINIMIZED AVERAGE STRUCTURE===




==Overview==
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In this work, we present the first NMR solution structure of a DNA/RNA hybrid containing stereoregular Rp-phosphorothioate modifications of all DNA backbone linkages. The complex of the enzymatically synthesized phosphorothioate DNA octamer (all-Rp)-d(GCGTCAGG) and its complementary RNA r(CCUGACGC) was found to adopt an overall conformation within the A-form family. Most helical parameters and the sugar puckers of the DNA strand assume values intermediate between A- and B-form. The close structural similarity with the unmodified DNA/RNA hybrid of the same sequence may explain why both the natural and the sulfur-substituted complex can be recognized and digested by ribonuclease H.
The line below this paragraph, {{ABSTRACT_PUBMED_9546216}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 9546216 is the PubMed ID number.
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{{ABSTRACT_PUBMED_9546216}}


==About this Structure==
==About this Structure==
Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8PSH OCA].  
Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8PSH OCA].  


==Reference==
==Reference==
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[[Category: Phosphorothioate]]
[[Category: Phosphorothioate]]
[[Category: Thionucleotide]]
[[Category: Thionucleotide]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 22:51:35 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri Jul 11 12:50:45 2008''

Revision as of 09:50, 11 July 2008

File:8psh.png

Template:STRUCTURE 8psh

HIGH RESOLUTION NMR STRUCTURE OF THE STEREOREGULAR (ALL-RP)-PHOSPHOROTHIOATE-DNA/RNA HYBRID D (G*PS*C*PS*G*PS*T*PS*C*PS*A*PS*G*PS*G)R(CCUGACGC), MINIMIZED AVERAGE STRUCTURE

Template:ABSTRACT PUBMED 9546216

About this Structure

Full experimental information is available from OCA.

Reference

Structure of a stereoregular phosphorothioate DNA/RNA duplex., Bachelin M, Hessler G, Kurz G, Hacia JG, Dervan PB, Kessler H, Nat Struct Biol. 1998 Apr;5(4):271-6. PMID:9546216

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