9gaf: Difference between revisions

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[[Image:9gaf.gif|left|200px]]
{{Seed}}
[[Image:9gaf.png|left|200px]]


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{{STRUCTURE_9gaf|  PDB=9gaf  |  SCENE=  }}  
{{STRUCTURE_9gaf|  PDB=9gaf  |  SCENE=  }}  


'''PRECURSOR OF THE W11F MUTANT GLYCOSYLASPARAGINASE FROM FLAVOBACTERIUM MENINGOSEPTICUM'''
===PRECURSOR OF THE W11F MUTANT GLYCOSYLASPARAGINASE FROM FLAVOBACTERIUM MENINGOSEPTICUM===




==Overview==
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A variety of proteins, including glycosylasparaginase, have recently been found to activate functions by self-catalyzed peptide bond rearrangements from single-chain precursors. Here we present the 1.9 A crystal structures of glycosylasparaginase precursors that are able to autoproteolyze via an N --&gt; O acyl shift. Several conserved residues are aligned around the scissile peptide bond that is in a highly strained trans peptide bond configuration. The structure illustrates how a nucleophilic side chain may attack the scissile peptide bond at the immediate upstream backbone carbonyl and provides an understanding of the structural basis for peptide bond cleavage via an N --&gt; O or N --&gt; S acyl shift that is used by various groups of intramolecular autoprocessing proteins.
The line below this paragraph, {{ABSTRACT_PUBMED_10490104}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 10490104 is the PubMed ID number.
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{{ABSTRACT_PUBMED_10490104}}


==About this Structure==
==About this Structure==
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[[Category: N-terminal nucleophile hydrolase]]
[[Category: N-terminal nucleophile hydrolase]]
[[Category: Precursor]]
[[Category: Precursor]]
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