3cpj: Difference between revisions

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[[Image:3cpj.jpg|left|200px]]
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{{STRUCTURE_3cpj|  PDB=3cpj  |  SCENE=  }}  
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'''Crystal structure of Ypt31 in complex with yeast Rab-GDI'''
===Crystal structure of Ypt31 in complex with yeast Rab-GDI===




==Overview==
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RabGDI-facilitated extraction of prenylated Rab proteins from membranes plays an important role in vesicular membrane trafficking. The investigated thermodynamic properties of yeast Rab:GDI and Rab:MRS6 complexes demonstrated differences in the Rab binding properties of the closely related RabGDI and MRS6 proteins, consistent with their functional diversity. The importance of the Rab C-terminus and its prenylation for GDI/MRS6 binding was demonstrated using both biochemical and structural data. The presented structures of the apo-form yeast RabGDI and its two complexes with unprenylated Rab proteins, together with the earlier published structures of the prenylated Ypt1:RabGDI provide evidence of allosteric regulation of the GDI lipid binding site opening, which plays a key role in the proposed mechanism of GDI mediated Rab extraction. We suggest a model for the interaction of GDI with prenylated Rab proteins which incorporates a stepwise increase in affinity as the 3 different partial interactions are successively formed.
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==About this Structure==
==About this Structure==
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[[Category: Rab gtpase]]
[[Category: Rab gtpase]]
[[Category: Vesicular transport]]
[[Category: Vesicular transport]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed May  7 08:56:28 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 16 08:54:31 2008''

Revision as of 05:54, 16 July 2008

File:3cpj.png

Template:STRUCTURE 3cpj

Crystal structure of Ypt31 in complex with yeast Rab-GDI

Template:ABSTRACT PUBMED 18426803

About this Structure

3CPJ is a Protein complex structure of sequences from Saccharomyces cerevisiae. Full crystallographic information is available from OCA.

Reference

A structural model of the GDI rab membrane extraction mechanism., Ignatev A, Kravchenko S, Rak A, Goody RS, Pylypenko O, J Biol Chem. 2008 Apr 20;. PMID:18426803

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