2pvm: Difference between revisions

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[[Image:2pvm.jpg|left|200px]]
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{{STRUCTURE_2pvm|  PDB=2pvm  |  SCENE=  }}  
{{STRUCTURE_2pvm|  PDB=2pvm  |  SCENE=  }}  


'''Structure-Based Design of Pyrazolo[1,5-a][1,3,5]triazine Derivatives as Potent Inhibitors of Protein Kinase CK2'''
===Structure-Based Design of Pyrazolo[1,5-a][1,3,5]triazine Derivatives as Potent Inhibitors of Protein Kinase CK2===




==Overview==
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The structure-based design, synthesis, and anticancer activity of novel inhibitors of protein kinase CK2 are described. Using pyrazolo[1,5-a][1,3,5]triazine as the core scaffold, a structure-guided series of modifications provided pM inhibitors with microM-level cytotoxic activity in cell-based assays with prostate and colon cancer cell lines.
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{{ABSTRACT_PUBMED_17540560}}


==About this Structure==
==About this Structure==
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[[Category: Structure-based drug design]]
[[Category: Structure-based drug design]]
[[Category: Transferase]]
[[Category: Transferase]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed May 14 11:21:54 2008''
 
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