2vdw: Difference between revisions

From Proteopedia
Jump to navigationJump to search
Newer edit →
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,328,572 edits
New page: left|200px <!-- The line below this paragraph, containing "STRUCTURE_2vdw", creates the "Structure Box" on the page. You may change the PDB parameter (which sets the PD...
 
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,328,572 edits
No edit summary
Line 1: Line 1:
[[Image:2vdw.jpg|left|200px]]
{{Seed}}
[[Image:2vdw.png|left|200px]]


<!--
<!--
Line 9: Line 10:
{{STRUCTURE_2vdw|  PDB=2vdw  |  SCENE=  }}  
{{STRUCTURE_2vdw|  PDB=2vdw  |  SCENE=  }}  


'''GUANOSINE N7 METHYL-TRANSFERASE SUB-COMPLEX (D1-D12) OF THE VACCINIA VIRUS MRNA CAPPING ENZYME'''
===GUANOSINE N7 METHYL-TRANSFERASE SUB-COMPLEX (D1-D12) OF THE VACCINIA VIRUS MRNA CAPPING ENZYME===




==Overview==
<!--
The vaccinia virus mRNA capping enzyme is a multifunctional heterodimeric protein associated with the viral polymerase that both catalyses the three steps of mRNA capping and regulates gene transcription. The structure of a subcomplex comprising the C-terminal N7-methyl-transferase (MT) domain of the large D1 subunit, the stimulatory D12 subunit and bound S-adenosyl-homocysteine (AdoHcy) has been determined at 2.7 A resolution and reveals several novel features of the poxvirus capping enzyme. The structure shows for the first time the critical role played by the proteolytically sensitive N-terminus of the MT domain in binding the methyl donor and in catalysis. In addition, the poxvirus enzyme has a completely unique mode of binding of the adenosine moiety of AdoHcy, a feature that could be exploited for design of specific anti-poxviral compounds. The structure of the poxvirus-specific D12 subunit suggests that it was originally an RNA cap 2'O-MT that has evolved to a catalytically inactive form that has been retained for D1 stabilisation and MT activity enhancement through an allosteric mechanism.
The line below this paragraph, {{ABSTRACT_PUBMED_17989694}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 17989694 is the PubMed ID number.
-->
{{ABSTRACT_PUBMED_17989694}}


==About this Structure==
==About this Structure==
Line 40: Line 44:
[[Category: S-adenosyl-l-methionine]]
[[Category: S-adenosyl-l-methionine]]
[[Category: Transferase]]
[[Category: Transferase]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed May 14 11:24:47 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 19:30:58 2008''
Retrieved from "https://proteopedia.org/2vdw"