3c9c: Difference between revisions

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[[Image:3c9c.~~jpg~~|left|200px]]

[[Image:3c9c.png|left|200px]]

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~~'''~~Structural Basis of Histone H4 Recognition by p55~~'''~~

===Structural Basis of Histone H4 Recognition by p55===

~~==Overview==~~

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~~p55 is a common component of many chromatin-modifying complexes and has been shown to bind to histones. Here~~, ~~we present a crystal structure of Drosophila p55 bound~~ to ~~a histone H4 peptide. p55, a predicted WD40 repeat protein, recognizes~~ the ~~first helix of histone H4 via a binding pocket located~~ on ~~the side of a beta-propeller structure~~. ~~The pocket cannot accommodate the histone fold of H4~~, ~~which must be altered to allow p55 binding. Reconstitution experiments show that the binding pocket~~ is ~~important to~~ the ~~function of p55~~-~~containing complexes. These data demonstrate that WD40 repeat proteins use various surfaces to direct the modification of histones.~~

The line below this paragraph, {{ABSTRACT_PUBMED_18443147}}, adds the Publication Abstract to the page

(as it appears on PubMed at http://www.pubmed.gov), where 18443147 is the PubMed ID number.

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==About this Structure==

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[[Category: Wd repeat]]

[[Category: Wd4]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Wed May 14~~ 11:~~32:12~~ 2008''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 19:11:06 2008''

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-[[Image:3c9c.jpg|left|200px]]
+{{Seed}}
+[[Image:3c9c.png|left|200px]]
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 {{STRUCTURE_3c9c|  PDB=3c9c  |  SCENE=  }}
-'''Structural Basis of Histone H4 Recognition by p55'''
+===Structural Basis of Histone H4 Recognition by p55===
-==Overview==
+<!--
-p55 is a common component of many chromatin-modifying complexes and has been shown to bind to histones. Here, we present a crystal structure of Drosophila p55 bound to a histone H4 peptide. p55, a predicted WD40 repeat protein, recognizes the first helix of histone H4 via a binding pocket located on the side of a beta-propeller structure. The pocket cannot accommodate the histone fold of H4, which must be altered to allow p55 binding. Reconstitution experiments show that the binding pocket is important to the function of p55-containing complexes. These data demonstrate that WD40 repeat proteins use various surfaces to direct the modification of histones.
+The line below this paragraph, {{ABSTRACT_PUBMED_18443147}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 18443147 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_18443147}}
 ==About this Structure==
@@ Line 42: / Line 46: @@
 [[Category: Wd repeat]]
 [[Category: Wd4]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed May 14 11:32:12 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 19:11:06 2008''