2r9y: Difference between revisions

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[[Image:2r9y.jpg|left|200px]]
{{Seed}}
[[Image:2r9y.png|left|200px]]


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{{STRUCTURE_2r9y|  PDB=2r9y  |  SCENE=  }}  
{{STRUCTURE_2r9y|  PDB=2r9y  |  SCENE=  }}  


'''Structure of antiplasmin'''
===Structure of antiplasmin===




==Overview==
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The serpin alpha(2)-antiplasmin (SERPINF2) is the principal inhibitor of plasmin and inhibits fibrinolysis. Accordingly, alpha(2)-antiplasmin deficiency in humans results in uncontrolled fibrinolysis and a bleeding disorder. alpha(2)-antiplasmin is an unusual serpin, in that it contains extensive N- and C-terminal sequences flanking the serpin domain. The N-terminal sequence is crosslinked to fibrin by factor XIIIa, whereas the C-terminal region mediates the initial interaction with plasmin. To understand how this may happen, we have determined the 2.65A X-ray crystal structure of an N-terminal truncated murine alpha(2)-antiplasmin. The structure reveals that part of the C-terminal sequence is tightly associated with the body of the serpin. This would be anticipated to position the flexible plasmin-binding portion of the C-terminus in close proximity to the serpin Reactive Center Loop where it may act as a template to accelerate serpin/protease interactions.
The line below this paragraph, {{ABSTRACT_PUBMED_18063751}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 18063751 is the PubMed ID number.
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{{ABSTRACT_PUBMED_18063751}}


==About this Structure==
==About this Structure==
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[[Category: Sulfation]]
[[Category: Sulfation]]
[[Category: Toxin]]
[[Category: Toxin]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed May 14 11:39:15 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 03:41:31 2008''

Revision as of 00:41, 28 July 2008

File:2r9y.png

Template:STRUCTURE 2r9y

Structure of antiplasmin

Template:ABSTRACT PUBMED 18063751

About this Structure

2R9Y is a Single protein structure of sequence from Mus musculus. Full crystallographic information is available from OCA.

Reference

X-ray crystal structure of the fibrinolysis inhibitor {alpha}2-antiplasmin., Law RH, Sofian T, Kan WT, Horvath AJ, Hitchen CR, Langendorf CG, Buckle AM, Whisstock JC, Coughlin PB, Blood. 2008 Feb 15;111(4):2049-52. Epub 2007 Dec 6. PMID:18063751

Page seeded by OCA on Mon Jul 28 03:41:31 2008

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