1b8q: Difference between revisions

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[[Image:1b8q.gif|left|200px]]<br /><applet load="1b8q" size="~~450~~" color="white" frame="true" align="right" spinBox="true"

[[Image:1b8q.gif|left|200px]]<br /><applet load="1b8q" size="350" color="white" frame="true" align="right" spinBox="true"

caption="1b8q" />

'''SOLUTION STRUCTURE OF THE EXTENDED NEURONAL NITRIC OXIDE SYNTHASE PDZ DOMAIN COMPLEXED WITH AN ASSOCIATED PEPTIDE'''<br />

==Overview==

The PDZ domain of neuronal nitric oxide synthase (nNOS) functions as a, scaffold for organizing the signal transduction complex of the enzyme. The, NMR structure of a complex composed of the nNOS PDZ domain and an, associated peptide suggests that a two-stranded beta-sheet C-terminal to, the canonical PDZ domain may mediate its interaction with the PDZ domains, of postsynaptic density-95 and alpha-syntrophin. The structure also, provides the molecular basis of recognition of Asp-X-Val-COOH peptides by, the nNOS PDZ domain. The role of the C-terminal extension in, Asp-X-Val-COOH peptide binding is investigated. Additionally, NMR studies, further show that the Asp-X-Val-COOH peptide and a C-terminal peptide from, a novel cytosolic protein named CAPON bind to the same pocket of the nNOS, PDZ domain.

The PDZ domain of neuronal nitric oxide synthase (nNOS) functions as a scaffold for organizing the signal transduction complex of the enzyme. The NMR structure of a complex composed of the nNOS PDZ domain and an associated peptide suggests that a two-stranded beta-sheet C-terminal to the canonical PDZ domain may mediate its interaction with the PDZ domains of postsynaptic density-95 and alpha-syntrophin. The structure also provides the molecular basis of recognition of Asp-X-Val-COOH peptides by the nNOS PDZ domain. The role of the C-terminal extension in Asp-X-Val-COOH peptide binding is investigated. Additionally, NMR studies further show that the Asp-X-Val-COOH peptide and a C-terminal peptide from a novel cytosolic protein named CAPON bind to the same pocket of the nNOS PDZ domain.

==About this Structure==

1B8Q is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://~~ispc~~.weizmann.ac.il/oca-bin/ocashort?id=1B8Q OCA].

1B8Q is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1B8Q OCA].

==Reference==

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[[Category: pdz domain]]

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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 11:52:50 2008''

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@@ Line 1: / Line 1: @@
-[[Image:1b8q.gif|left|200px]]<br /><applet load="1b8q" size="450" color="white" frame="true" align="right" spinBox="true"
+[[Image:1b8q.gif|left|200px]]<br /><applet load="1b8q" size="350" color="white" frame="true" align="right" spinBox="true"
 caption="1b8q" />
 '''SOLUTION STRUCTURE OF THE EXTENDED NEURONAL NITRIC OXIDE SYNTHASE PDZ DOMAIN COMPLEXED WITH AN ASSOCIATED PEPTIDE'''<br />
 ==Overview==
-The PDZ domain of neuronal nitric oxide synthase (nNOS) functions as a, scaffold for organizing the signal transduction complex of the enzyme. The, NMR structure of a complex composed of the nNOS PDZ domain and an, associated peptide suggests that a two-stranded beta-sheet C-terminal to, the canonical PDZ domain may mediate its interaction with the PDZ domains, of postsynaptic density-95 and alpha-syntrophin. The structure also, provides the molecular basis of recognition of Asp-X-Val-COOH peptides by, the nNOS PDZ domain. The role of the C-terminal extension in, Asp-X-Val-COOH peptide binding is investigated. Additionally, NMR studies, further show that the Asp-X-Val-COOH peptide and a C-terminal peptide from, a novel cytosolic protein named CAPON bind to the same pocket of the nNOS, PDZ domain.
+The PDZ domain of neuronal nitric oxide synthase (nNOS) functions as a scaffold for organizing the signal transduction complex of the enzyme. The NMR structure of a complex composed of the nNOS PDZ domain and an associated peptide suggests that a two-stranded beta-sheet C-terminal to the canonical PDZ domain may mediate its interaction with the PDZ domains of postsynaptic density-95 and alpha-syntrophin. The structure also provides the molecular basis of recognition of Asp-X-Val-COOH peptides by the nNOS PDZ domain. The role of the C-terminal extension in Asp-X-Val-COOH peptide binding is investigated. Additionally, NMR studies further show that the Asp-X-Val-COOH peptide and a C-terminal peptide from a novel cytosolic protein named CAPON bind to the same pocket of the nNOS PDZ domain.
 ==About this Structure==
-B8Q is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1B8Q OCA].
+B8Q is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1B8Q OCA].
 ==Reference==
@@ Line 22: / Line 22: @@
 [[Category: pdz domain]]
-''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Nov 20 11:27:34 2007''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 11:52:50 2008''