3cen: Difference between revisions

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New page: left|200px <!-- The line below this paragraph, containing "STRUCTURE_3cen", creates the "Structure Box" on the page. You may change the PDB parameter (which sets the PD...
 
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[[Image:3cen.jpg|left|200px]]
{{Seed}}
[[Image:3cen.png|left|200px]]


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{{STRUCTURE_3cen|  PDB=3cen  |  SCENE=  }}  
{{STRUCTURE_3cen|  PDB=3cen  |  SCENE=  }}  


'''Factor XA in complex with the inhibitor N-(2-(((5-chloro-2-pyridinyl) amino)sulfonyl)phenyl)-4-(2-oxo-1(2H)-pyridinyl)benzamide'''
===Factor XA in complex with the inhibitor N-(2-(((5-chloro-2-pyridinyl) amino)sulfonyl)phenyl)-4-(2-oxo-1(2H)-pyridinyl)benzamide===




==Overview==
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Introduction of the phenyl piperidinone and phenyl pyridinone P4 moieties in the anthranilamide scaffold led to potent, selective, and orally bioavailable inhibitors of factor Xa. Anthranilamide 28 displayed comparable efficacy to apixaban in the rabbit arteriovenous-shunt (AV) thrombosis model.
The line below this paragraph, {{ABSTRACT_PUBMED_18424044}}, adds the Publication Abstract to the page
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{{ABSTRACT_PUBMED_18424044}}


==About this Structure==
==About this Structure==
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[[Category: Serine protease]]
[[Category: Serine protease]]
[[Category: Zymogen]]
[[Category: Zymogen]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu May 22 22:01:04 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 16:17:15 2008''
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