2uvx: Difference between revisions

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[[Image:2uvx.jpg|left|200px]]
{{Seed}}
[[Image:2uvx.png|left|200px]]


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{{STRUCTURE_2uvx|  PDB=2uvx  |  SCENE=  }}  
{{STRUCTURE_2uvx|  PDB=2uvx  |  SCENE=  }}  


'''STRUCTURE OF PKA-PKB CHIMERA COMPLEXED WITH 7-AZAINDOLE'''
===STRUCTURE OF PKA-PKB CHIMERA COMPLEXED WITH 7-AZAINDOLE===




==Overview==
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6-phenylpurines were identified as novel, ATP-competitive inhibitors of protein kinase B (PKB/Akt) from a fragment-based screen and were rapidly progressed to potent compounds using iterative protein-ligand crystallography with a PKA-PKB chimeric protein. An elaborated lead compound showed cell growth inhibition and effects on cellular signaling pathways characteristic of PKB inhibition.
The line below this paragraph, {{ABSTRACT_PUBMED_17451235}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 17451235 is the PubMed ID number.
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{{ABSTRACT_PUBMED_17451235}}


==About this Structure==
==About this Structure==
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[[Category: Transferase]]
[[Category: Transferase]]
[[Category: Transferase/inhibitor complex]]
[[Category: Transferase/inhibitor complex]]
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