1viw: Difference between revisions

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{{STRUCTURE_1viw|  PDB=1viw  |  SCENE=  }}  
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'''TENEBRIO MOLITOR ALPHA-AMYLASE-INHIBITOR COMPLEX'''
===TENEBRIO MOLITOR ALPHA-AMYLASE-INHIBITOR COMPLEX===




==Overview==
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The alpha-amylase from Tenebrio molitor larvae (TMA) has been crystallized in complex with the alpha-amylase inhibitor (alpha-AI) from the bean Phaseolus vulgaris. A molecular-replacement solution of the structure was obtained using the refined pig pancreatic alpha-amylase (PPA) and alpha-AI atomic coordinates as starting models. The structural analysis showed that although TMA has the typical structure common to alpha-amylases, large deviations from the mammalian alpha-amylase models occur in the loops. Despite these differences in the interacting loops, the bean inhibitor is still able to inhibit both the insect and mammalian alpha-amylase.
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==About this Structure==
==About this Structure==
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[[Category: Insect alpha-amylase]]
[[Category: Insect alpha-amylase]]
[[Category: Lectin]]
[[Category: Lectin]]
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