2jr3: Difference between revisions

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{{STRUCTURE_2jr3|  PDB=2jr3  |  SCENE=  }}  
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'''Antibacterial Peptide from Eggshell Matrix: Structure and Self-assembly of beta-defensin Like Peptide from the Chinese Soft-shelled Turtle Eggshell'''
===Antibacterial Peptide from Eggshell Matrix: Structure and Self-assembly of beta-defensin Like Peptide from the Chinese Soft-shelled Turtle Eggshell===




==Overview==
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Biomineral matrix formation and molecular recognition are two important processes associated with eggshell biomineralization. To understand these two processes, a major intracrystalline peptide, pelovaterin, was isolated from turtle (Pelodiscus sinensis) eggshell and its tertiary and quaternary structures were established. The global fold of pelovaterin is similar to that of human beta-defensins but has a large hydrophobic core and a short hydrophilic N-terminal segment, which is not preserved in defensins. Pelovaterin exhibits strong antimicrobial activity against two pathogenic gram-negative bacteria, Pseudomonas aeruginosa and Proteus vulgaris, and stabilizes a thin film of metastable vaterite. We show that pelovaterin self-aggregates in the form of micellar nanospheres and the aggregation in solution is entropy-driven. It is suggested that the micellar aggregation of pelovaterin is responsible for the induction and stabilization of the metastable phase by altering the interfacial energy. The results demonstrate the adaptability of an extracellular matrix protein to perform multiple tasks: polymorph discrimination and protection of the contents of the egg against bacterial invasion.
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==About this Structure==
==About this Structure==
2JR3 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Pelodiscus_sinensis Pelodiscus sinensis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JR3 OCA].  
2JR3 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Pelodiscus_sinensis Pelodiscus sinensis]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JR3 OCA].  


==Reference==
==Reference==
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[[Category: Chinese soft-shelled turtle eggshell]]
[[Category: Chinese soft-shelled turtle eggshell]]
[[Category: Eggshell matrix]]
[[Category: Eggshell matrix]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed May 28 09:11:12 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 13:00:59 2008''

Revision as of 10:01, 27 July 2008

File:2jr3.png

Template:STRUCTURE 2jr3

Antibacterial Peptide from Eggshell Matrix: Structure and Self-assembly of beta-defensin Like Peptide from the Chinese Soft-shelled Turtle Eggshell

Template:ABSTRACT PUBMED 18341335

About this Structure

2JR3 is a Single protein structure of sequence from Pelodiscus sinensis. Full experimental information is available from OCA.

Reference

Structure, self-assembly, and dual role of a beta-defensin-like peptide from the Chinese soft-shelled turtle eggshell matrix., Lakshminarayanan R, Vivekanandan S, Samy RP, Banerjee Y, Chi-Jin EO, Teo KW, Jois SD, Kini RM, Valiyaveettil S, J Am Chem Soc. 2008 Apr 9;130(14):4660-8. Epub 2008 Mar 15. PMID:18341335

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