2zcv: Difference between revisions

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{{STRUCTURE_2zcv|  PDB=2zcv  |  SCENE=  }}  
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'''Crystal structure of NADPH-dependent quinone oxidoreductase QOR2 complexed with NADPH from escherichia coli'''
===Crystal structure of NADPH-dependent quinone oxidoreductase QOR2 complexed with NADPH from escherichia coli===




==Overview==
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Escherichia coli QOR2 [NAD(P)H-dependent quinone oxidoreductase; a ytfG gene product], which catalyzes two-electron reduction of methyl-1,4-benzoquinone, is a new type of quinone-reducing enzyme with distinct primary sequence and oligomeric conformation from previously known quinone oxidoreductases. The crystal structures of native QOR2 and the QOR2-NADPH (nicotinamide adenine dinucleotide phosphate, reduced form) complex reveal that QOR2 consists of two domains (N-domain and C-domain) resembling those of NmrA, a negative transcriptional regulator that belongs to the short-chain dehydrogenase/reductase family. The N-domain, which adopts the Rossmann fold, provides a platform for NADPH binding, whereas the C-domain, which contains a hydrophobic pocket connected to the NADPH-binding site, appears to play important roles in substrate binding. Asn143 near the NADPH-binding site has been identified to be involved in substrate binding and catalysis from structural and mutational analyses. Moreover, compared with wild-type strain, the qor2-overexpressing strain shows growth retardation and remarkable decrease in several enzymes involved in carbon metabolism, suggesting that QOR2 could play some physiological roles in addition to quinone reduction.
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==About this Structure==
==About this Structure==
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[[Category: Complex with nadph]]
[[Category: Complex with nadph]]
[[Category: Oxidoreductase]]
[[Category: Oxidoreductase]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed May 28 09:18:13 2008''
 
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Revision as of 09:22, 29 July 2008

File:2zcv.png

Template:STRUCTURE 2zcv

Crystal structure of NADPH-dependent quinone oxidoreductase QOR2 complexed with NADPH from escherichia coli

Template:ABSTRACT PUBMED 18455185

About this Structure

2ZCV is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.

Reference

Crystal structure of a new type of NADPH-dependent quinone oxidoreductase (QOR2) from Escherichia coli., Kim IK, Yim HS, Kim MK, Kim DW, Kim YM, Cha SS, Kang SO, J Mol Biol. 2008 May 30;379(2):372-84. Epub 2008 Apr 8. PMID:18455185

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