3ctq: Difference between revisions

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{{Seed}}
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{{STRUCTURE_3ctq|  PDB=3ctq  |  SCENE=  }}  
{{STRUCTURE_3ctq|  PDB=3ctq  |  SCENE=  }}  


'''Structure of MAP kinase p38 in complex with a 1-o-tolyl-1,2,3-triazole-4-carboxamide'''
===Structure of MAP kinase p38 in complex with a 1-o-tolyl-1,2,3-triazole-4-carboxamide===




==Overview==
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A computer-aided drug design strategy leads to the identification of a new class of p38 inhibitors based on the 2-tolyl-(1,2,3-triazol-1-yl-4-carboxamide) scaffold. The tolyl triazole amides provided a potent platform amenable to optimization. Further exploration leads to compounds with greater than 100-fold improvement in binding affinity to p38. Derivatives prepared to alter the physicochemical properties produced inhibitors with IC(50)'s in human whole blood as low as 83nM.
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{{ABSTRACT_PUBMED_18462940}}


==About this Structure==
==About this Structure==
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[[Category: Transferase]]
[[Category: Transferase]]
[[Category: Two lobe kinase fold]]
[[Category: Two lobe kinase fold]]
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