3cd8: Difference between revisions

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[[Image:3cd8.jpg|left|200px]]
{{Seed}}
[[Image:3cd8.png|left|200px]]


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{{STRUCTURE_3cd8|  PDB=3cd8  |  SCENE=  }}  
{{STRUCTURE_3cd8|  PDB=3cd8  |  SCENE=  }}  


'''X-ray Structure of c-Met with triazolopyridazine Inhibitor.'''
===X-ray Structure of c-Met with triazolopyridazine Inhibitor.===




==Overview==
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Tumorigenesis is a multistep process in which oncogenes play a key role in tumor formation, growth, and maintenance. MET was discovered as an oncogene that is activated by its ligand, hepatocyte growth factor. Deregulated signaling in the c-Met pathway has been observed in multiple tumor types. Herein we report the discovery of potent and selective triazolopyridazine small molecules that inhibit c-Met activity.
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{{ABSTRACT_PUBMED_18426196}}


==Disease==
==Disease==
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[[Category: Triazolopyridazine]]
[[Category: Triazolopyridazine]]
[[Category: Tyrosine-protein kinase]]
[[Category: Tyrosine-protein kinase]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed May 28 09:38:23 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 01:12:00 2008''

Revision as of 22:12, 27 July 2008

File:3cd8.png

Template:STRUCTURE 3cd8

X-ray Structure of c-Met with triazolopyridazine Inhibitor.

Template:ABSTRACT PUBMED 18426196

Disease

Known disease associated with this structure: Hepatocellular carcinoma, childhood type OMIM:[164860], Renal cell carcinoma, papillary, familial and sporadic OMIM:[164860], Autism, suseptibility to, 9 OMIM:[164860]

About this Structure

3CD8 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Discovery and Optimization of Triazolopyridazines as Potent and Selective Inhibitors of the c-Met Kinase., Albrecht BK, Harmange JC, Bauer D, Berry L, Bode C, Boezio AA, Chen A, Choquette D, Dussault I, Fridrich C, Hirai S, Hoffman D, Larrow JF, Kaplan-Lefko P, Lin J, Lohman J, Long AM, Moriguchi J, O'Connor A, Potashman MH, Reese M, Rex K, Siegmund A, Shah K, Shimanovich R, Springer SK, Teffera Y, Yang Y, Zhang Y, Bellon SF, J Med Chem. 2008 May 22;51(10):2879-82. Epub 2008 Apr 22. PMID:18426196

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