1bqh: Difference between revisions

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[[Image:1bqh.gif|left|200px]]<br /><applet load="1bqh" size="~~450~~" color="white" frame="true" align="right" spinBox="true"

[[Image:1bqh.gif|left|200px]]<br /><applet load="1bqh" size="350" color="white" frame="true" align="right" spinBox="true"

caption="1bqh, resolution 2.8Å" />

'''MURINE CD8AA ECTODOMAIN FRAGMENT IN COMPLEX WITH H-2KB/VSV8'''<br />

==Overview==

The crystal structure of the two immunoglobulin variable-like domains of, the murine CD8alphaalpha homodimer complexed to the class I MHC H-2Kb, molecule at 2.8 A resolution shows that CD8alphaalpha binds to the, protruding MHC alpha3 domain loop in an antibody-like manner. Comparison, of mouse CD8alphaalpha/H-2Kb and human CD8alphaalpha/HLA-A2 complexes, reveals shared as well as species-specific recognition features. In both, species, coreceptor function apparently involves the participation of CD8, dimer in a bidentate attachment to an MHC class I molecule in conjunction, with a T cell receptor without discernable conformational alteration of, the peptide or MHC antigen-presenting platform.

The crystal structure of the two immunoglobulin variable-like domains of the murine CD8alphaalpha homodimer complexed to the class I MHC H-2Kb molecule at 2.8 A resolution shows that CD8alphaalpha binds to the protruding MHC alpha3 domain loop in an antibody-like manner. Comparison of mouse CD8alphaalpha/H-2Kb and human CD8alphaalpha/HLA-A2 complexes reveals shared as well as species-specific recognition features. In both species, coreceptor function apparently involves the participation of CD8 dimer in a bidentate attachment to an MHC class I molecule in conjunction with a T cell receptor without discernable conformational alteration of the peptide or MHC antigen-presenting platform.

==About this Structure==

1BQH is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus] with NDG and NAG as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://~~ispc~~.weizmann.ac.il/oca-bin/ocashort?id=1BQH OCA].

1BQH is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus] with <scene name='pdbligand=NDG:'>NDG</scene> and <scene name='pdbligand=NAG:'>NAG</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BQH OCA].

==Reference==

Line 13:

[[Category: Mus musculus]]

[[Category: Protein complex]]

[[Category: Chang, H.C.]]

[[Category: Chang, H C.]]

[[Category: Kern, P.S.]]

[[Category: Kern, P S.]]

[[Category: Reinherz, E.L.]]

[[Category: Reinherz, E L.]]

[[Category: Wang, J.H.]]

[[Category: Wang, J H.]]

[[Category: NAG]]

[[Category: NDG]]

Line 27:

[[Category: t-cell]]

''Page seeded by [http://~~ispc~~.weizmann.ac.il/oca OCA ] on ~~Tue Nov 20~~ 11:50:~~22 2007~~''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 11:58:00 2008''

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@@ Line 1: / Line 1: @@
-[[Image:1bqh.gif|left|200px]]<br /><applet load="1bqh" size="450" color="white" frame="true" align="right" spinBox="true"
+[[Image:1bqh.gif|left|200px]]<br /><applet load="1bqh" size="350" color="white" frame="true" align="right" spinBox="true"
 caption="1bqh, resolution 2.8&Aring;" />
 '''MURINE CD8AA ECTODOMAIN FRAGMENT IN COMPLEX WITH H-2KB/VSV8'''<br />
 ==Overview==
-The crystal structure of the two immunoglobulin variable-like domains of, the murine CD8alphaalpha homodimer complexed to the class I MHC H-2Kb, molecule at 2.8 A resolution shows that CD8alphaalpha binds to the, protruding MHC alpha3 domain loop in an antibody-like manner. Comparison, of mouse CD8alphaalpha/H-2Kb and human CD8alphaalpha/HLA-A2 complexes, reveals shared as well as species-specific recognition features. In both, species, coreceptor function apparently involves the participation of CD8, dimer in a bidentate attachment to an MHC class I molecule in conjunction, with a T cell receptor without discernable conformational alteration of, the peptide or MHC antigen-presenting platform.
+The crystal structure of the two immunoglobulin variable-like domains of the murine CD8alphaalpha homodimer complexed to the class I MHC H-2Kb molecule at 2.8 A resolution shows that CD8alphaalpha binds to the protruding MHC alpha3 domain loop in an antibody-like manner. Comparison of mouse CD8alphaalpha/H-2Kb and human CD8alphaalpha/HLA-A2 complexes reveals shared as well as species-specific recognition features. In both species, coreceptor function apparently involves the participation of CD8 dimer in a bidentate attachment to an MHC class I molecule in conjunction with a T cell receptor without discernable conformational alteration of the peptide or MHC antigen-presenting platform.
 ==About this Structure==
-BQH is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus] with NDG and NAG as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1BQH OCA].
+BQH is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus] with <scene name='pdbligand=NDG:'>NDG</scene> and <scene name='pdbligand=NAG:'>NAG</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BQH OCA].
 ==Reference==
@@ Line 13: / Line 13: @@
 [[Category: Mus musculus]]
 [[Category: Protein complex]]
-[[Category: Chang, H.C.]]
+[[Category: Chang, H C.]]
-[[Category: Kern, P.S.]]
+[[Category: Kern, P S.]]
-[[Category: Reinherz, E.L.]]
+[[Category: Reinherz, E L.]]
-[[Category: Wang, J.H.]]
+[[Category: Wang, J H.]]
 [[Category: NAG]]
 [[Category: NDG]]
@@ Line 27: / Line 27: @@
 [[Category: t-cell]]
-''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Nov 20 11:50:22 2007''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 11:58:00 2008''