1hj7: Difference between revisions
New page: left|200px<br /> <applet load="1hj7" size="450" color="white" frame="true" align="right" spinBox="true" caption="1hj7" /> '''NMR STUDY OF A PAIR OF LDL RECEPTOR CA2+ BI... |
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==About this Structure== | ==About this Structure== | ||
1HJ7 is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]] with CA as [[http://en.wikipedia.org/wiki/ligand ligand]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1HJ7 OCA]]. | 1HJ7 is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]] with CA as [[http://en.wikipedia.org/wiki/ligand ligand]]. Structure known Active Sites: CA1 and CA2. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1HJ7 OCA]]. | ||
==Reference== | ==Reference== | ||
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[[Category: vldl]] | [[Category: vldl]] | ||
''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 12:34:31 2007'' | ||
Revision as of 10:29, 30 October 2007
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NMR STUDY OF A PAIR OF LDL RECEPTOR CA2+ BINDING EPIDERMAL GROWTH FACTOR-LIKE DOMAINS, 20 STRUCTURES
Overview
BACKGROUND: From the observed structure and sequence of a pair of calcium, binding (cb) epidermal growth factor-like (EGF) domains from human, fibrillin-1, we proposed that many tandem cbEGF domains adopt a conserved, relative conformation. The low-density lipoprotein receptor (LDLR), which, is functionally unrelated to fibrillin-1, contains a single pair of EGF, domains that was chosen for study in the validation of this hypothesis., The LDLR is the protein that is defective in familial, hypercholesterolaemia, a common genetic disorder that predisposes, individuals to cardiovascular complications and premature death. RESULTS:, Here, we present the solution structure of the first two EGF domains from, the LDL receptor, determined using conventional NMR restraints and, residual dipolar ... [(full description)]
About this Structure
1HJ7 is a [Single protein] structure of sequence from [Homo sapiens] with CA as [ligand]. Structure known Active Sites: CA1 and CA2. Full crystallographic information is available from [OCA].
Reference
Solution structure of the LDL receptor EGF-AB pair: a paradigm for the assembly of tandem calcium binding EGF domains., Saha S, Boyd J, Werner JM, Knott V, Handford PA, Campbell ID, Downing AK, Structure. 2001 Jun;9(6):451-6. PMID:11435110
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