Acid-beta-glucosidase: Difference between revisions

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Acid-beta-glucosidase for treatment of a Gaucher disease is produced in CHO cells (Cerezyme™) ([[1ogs]];[[1y7v]];[[2f61]]; [[2nt0]]; [[2nt1]]; [[2v3d]]; [[2v3e]]; [[2nsx]]; [[2j25]]) or in a carrot stem cells suspension (plant produced enzyme by Protalix biopharmaceuticals, [[2v3d]]; [[2v3f]]; [[2v3e]]). Recently solved structures of both enzymes indicate the enzymes are virtually <scene name='Acid-beta-glucosidase/Overlay/1'>identical </scene>in their 3D structures. Yet some small insignificant differences in sugars arise due to the use of different expression systems.

Acid-beta-glucosidase: Difference between revisions

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Revision as of 08:14, 3 June 2008 view source Boris Brumshtein (talk \| contribs) 64 edits No edit summary ← Older edit		Revision as of 08:20, 3 June 2008 view source Boris Brumshtein (talk \| contribs) 64 edits No edit summary Newer edit →
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	<applet load='2V3F-A_2j25-B.pdb' size='300' frame='true' align='right' caption='Cerezyme is shown in ~~grey~~ and Protalix enzyme in ~~blue~~' />		<applet load='2V3F-A_2j25-B.pdb' size='300' frame='true' align='right' caption='Cerezyme is shown in cyan and Protalix enzyme in green' />



	Acid-beta-glucosidase for treatment of a Gaucher disease is produced in CHO cells (Cerezyme™) ([[1ogs]];[[1y7v]];[[2f61]]; [[2nt0]]; [[2nt1]]; [[2v3d]]; [[2v3e]]; [[2nsx]]; [[2j25]]) or in a carrot stem cells suspension (plant produced enzyme by Protalix biopharmaceuticals, [[2v3d]]; [[2v3f]]; [[2v3e]]). Recently solved structures of both enzymes indicate the enzymes are virtually <scene name='Acid-beta-glucosidase/Overlay/1'>identical </scene>in their 3D structures. Yet some small insignificant differences in sugars arise due to the use of different expression systems.		Acid-beta-glucosidase for treatment of a Gaucher disease is produced in CHO cells (Cerezyme™) ([[1ogs]];[[1y7v]];[[2f61]]; [[2nt0]]; [[2nt1]]; [[2v3d]]; [[2v3e]]; [[2nsx]]; [[2j25]]) or in a carrot stem cells suspension (plant produced enzyme by Protalix biopharmaceuticals, [[2v3d]]; [[2v3f]]; [[2v3e]]). Recently solved structures of both enzymes indicate the enzymes are virtually <scene name='Acid-beta-glucosidase/Overlay/1'>identical </scene>in their 3D structures. Yet some small insignificant differences in sugars arise due to the use of different expression systems.