2z1y: Difference between revisions

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{{STRUCTURE_2z1y|  PDB=2z1y  |  SCENE=  }}  
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'''Crystal structure of LysN, alpha-aminoadipate aminotransferase (complexed with N-(5'-phosphopyridoxyl)-L-leucine), from Thermus thermophilus HB27'''
===Crystal structure of LysN, alpha-aminoadipate aminotransferase (complexed with N-(5'-phosphopyridoxyl)-L-leucine), from Thermus thermophilus HB27===


==Overview==
The extremely thermophilic bacterium Thermus thermophilus HB27 synthesizes lysine through alpha-aminoadipate (AAA). In this study, a T. thermophilus gene encoding the enzyme that catalyses transamination of AAA was cloned as a mammalian kynurenine/AAA aminotransferase (Kat2) gene homologue. A T. thermophilus mutant with disruption of the Kat2 homologue required a longer lag phase for growth and showed slower growth in minimal medium. Furthermore, addition of AAA or lysine shortened the lag phase and improved the growth rate. The Kat2 homologue was therefore termed lysN. LysN recognizes not only 2-oxoadipate, an intermediate of lysine biosynthesis, but also 2-oxoisocaproate, 2-oxoisovalerate and 2-oxo-3-methylvalerate, intermediates of leucine, valine and isoleucine biosyntheses, respectively, along with oxaloacetate, a compound in the TCA cycle, as an amino acceptor. These results suggest multiple roles of LysN in several cellular metabolic pathways including lysine and branched-chain amino acid biosyntheses.


==About this Structure==
==About this Structure==
2Z1Y is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Thermus_thermophilus Thermus thermophilus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Z1Y OCA].  
2Z1Y is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Thermus_thermophilus Thermus thermophilus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Z1Y OCA].  


==Reference==
==Reference==
alpha-Aminoadipate aminotransferase from an extremely thermophilic bacterium, Thermus thermophilus., Miyazaki T, Miyazaki J, Yamane H, Nishiyama M, Microbiology. 2004 Jul;150(Pt 7):2327-34. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15256574 15256574]
<ref group="xtra">PMID:15256574</ref><references group="xtra"/>
[[Category: 2-aminoadipate transaminase]]
[[Category: 2-aminoadipate transaminase]]
[[Category: Single protein]]
[[Category: Thermus thermophilus]]
[[Category: Thermus thermophilus]]
[[Category: Fushinobu, S.]]
[[Category: Fushinobu, S.]]
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[[Category: Substrate specifity]]
[[Category: Substrate specifity]]
[[Category: Thermus thermophilus]]
[[Category: Thermus thermophilus]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 20:48:56 2009''

Revision as of 18:48, 17 February 2009

File:2z1y.png

Template:STRUCTURE 2z1y

Crystal structure of LysN, alpha-aminoadipate aminotransferase (complexed with N-(5'-phosphopyridoxyl)-L-leucine), from Thermus thermophilus HB27

About this Structure

2Z1Y is a 2 chains structure of sequences from Thermus thermophilus. Full crystallographic information is available from OCA.

Reference

  1. Miyazaki T, Miyazaki J, Yamane H, Nishiyama M. alpha-Aminoadipate aminotransferase from an extremely thermophilic bacterium, Thermus thermophilus. Microbiology. 2004 Jul;150(Pt 7):2327-34. PMID:15256574 doi:10.1099/mic.0.27037-0

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