3ckr: Difference between revisions

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[[Image:3ckr.jpg|left|200px]]
{{Seed}}
[[Image:3ckr.png|left|200px]]


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{{STRUCTURE_3ckr|  PDB=3ckr  |  SCENE=  }}  
{{STRUCTURE_3ckr|  PDB=3ckr  |  SCENE=  }}  


'''Crystal structure of BACE-1 in complex with inhibitor'''
===Crystal structure of BACE-1 in complex with inhibitor===




==Overview==
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We describe synthesis and evaluation of a series of cyclic urea derivatives with hydroxylethylamine isostere. Modification of P3, P1, and P2' and combination of SAR display a &gt;100-fold increase in potency with good cellular activity (IC(50)=0.15microM) relative to the previously reported compound 3.
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{{ABSTRACT_PUBMED_18434152}}


==About this Structure==
==About this Structure==
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[[Category: Transmembrane]]
[[Category: Transmembrane]]
[[Category: Zymogen]]
[[Category: Zymogen]]
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