User:Boris Brumshtein: Difference between revisions

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=CV=

==CV==

==Personal Information==

===Personal Information===

Name: Boris Brumshtein

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Current residence: Rehovot, Israel.

==Contact Information==

===Contact Information===

Department of Structural Biology, Weizmann Institute of Science

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+972-8-9342647 (work)

==Education==

===Education===

2003 - present Direct PhD program at the Weizmann Institute of Science, Faculty of Chemistry, Department of Structural Biology.

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1999-2002 BA in Biochemistry, Technion, Israel Institute of Science and Technology, Faculty of Chemistry, cum laude.

==Qualifications==

===Qualifications===

In my research I employ different protein biochemistry, enzymology and crystallography methods, thus I gained a lot of experience in the following techniques:

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-Unix, C, Perl, Matlab, Java (basic programming).

==LIST OF PUBLICATIONS==

# Brumshtein B, Greenblatt HM, Butters TD, Shaaltiel Y, Aviezer D, Silman I, Futerman AH, Sussman JL. Crystal structures of complexes of N-butyl- and N-nonyl-deoxynojirimycin bound to acid-beta -glucosidase: Insights into the mechanism of chemical chaperone action in Gaucher disease. J.Biol. Chem., Vol. 282, Issue 39, 29052-29058, (2007).

# Brumshtein, B., Wormald, M. R., Silman, I., Futerman, A. H. & Sussman, J. L. Structural comparison of differently glycosylated forms of acid-beta-glucosidase, the defective enzyme in Gaucher disease. Acta Crystallogr D Biol Crystallogr 62, 1458-65 (2006).

# Rydberg EH, Brumshtein B, Greenblatt HM, Wong DM, Shaya D, Williams LD, Carlier PR, Pang YP, Silman I, Sussman JL. Complexes of alkylene-linked tacrine dimers with Torpedo californica acetylcholinesterase: Binding of Bis5- tacrine produces a dramatic rearrangement in the active-site gorge. J Med Chem 49, 5491-500 (2006).

# Harel M, Hyatt JL, Brumshtein B, Morton CL, Wadkins RM, Silman I, Sussman JL, Potter PM. The 3D structure of the anticancer prodrug CPT-11 with Torpedo californica acetylcholinesterase rationalizes its inhibitory action on AChE and its hydrolysis by butyrylcholinesterase and carboxylesterase. Chem Biol Interact 157-158, 153-7 (2005).

# Hyatt JL, Tsurkan L, Morton CL, Yoon KJ, Harel M, Brumshtein B, Silman I, Sussman JL, Wadkins RM, Potter PM. Inhibition of acetylcholinesterase by the anticancer prodrug CPT-11. Chem Biol Interact 157-158, 247-52 (2005).

# Harel M, Hyatt JL, Brumshtein B, Morton CL, Yoon KJ, Wadkins RM, Silman I, Sussman JL, Potter PM. The crystal structure of the complex of the anticancer prodrug 7-ethyl-10-[4-(1-piperidino)-1-piperidino]-carbonyloxycamptothecin (CPT- 11) with Torpedo californica acetylcholinesterase provides a molecular explanation for its cholinergic action. Mol Pharmacol 67, 1874-81 (2005).

# Harel M, Aharoni A, Gaidukov L, Brumshtein B, Khersonsky O, Meged R, Dvir H, Ravelli RB, McCarthy A, Toker L, Silman I, Sussman JL, Tawfik DS. Structure and evolution of the serum paraoxonase family of detoxifying and anti-atherosclerotic enzymes. Nat Struct Mol Biol 11, 412-9 (2004).

# Adir, N., Rukhman, V., Brumshtein, B. & Anati, R. Preliminary X-ray crystallographic analysis of a soluble form of MntC, a periplasmic manganese- binding component of an ABC-type Mn transporter from Synechocystis sp. PCC 6803. Acta Crystallogr D Biol Crystallogr 58, 1476-8 (2002).

User:Boris Brumshtein: Difference between revisions

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@@ Line 1: / Line 1: @@
-=CV=
+==CV==
-==Personal Information==
+===Personal Information===
 Name: Boris Brumshtein
@@ Line 9: / Line 9: @@
 Current residence: Rehovot, Israel.
-==Contact Information==
+===Contact Information===
 Department of Structural Biology, Weizmann Institute of Science
@@ Line 19: / Line 19: @@
 		        +972-8-9342647 (work)
-==Education==
+===Education===
 - present  Direct PhD program at the Weizmann Institute of Science, Faculty of Chemistry, Department of Structural Biology.
@@ Line 30: / Line 30: @@
 -2002	BA in Biochemistry, Technion, Israel Institute of Science and Technology, Faculty of Chemistry, cum laude.
-==Qualifications==
+===Qualifications===
 In my research I employ different protein biochemistry, enzymology and crystallography methods, thus I gained a lot of experience in the following techniques:
@@ Line 67: / Line 67: @@
 -Unix, C, Perl, Matlab, Java (basic programming).
+==LIST OF PUBLICATIONS==
+# Brumshtein B, Greenblatt HM, Butters TD, Shaaltiel Y, Aviezer D, Silman I, Futerman AH, Sussman JL. Crystal structures of complexes of N-butyl- and N-nonyl-deoxynojirimycin bound to acid-beta -glucosidase: Insights into the mechanism of chemical chaperone action in Gaucher disease. J.Biol. Chem., Vol. 282, Issue 39, 29052-29058, (2007).
+# Brumshtein, B., Wormald, M. R., Silman, I., Futerman, A. H. & Sussman, J. L. Structural comparison of differently glycosylated forms of acid-beta-glucosidase, the defective enzyme in Gaucher disease. Acta Crystallogr D Biol Crystallogr 62, 1458-65 (2006).
+# Rydberg EH, Brumshtein B, Greenblatt HM, Wong DM, Shaya D, Williams LD, Carlier PR, Pang YP, Silman I, Sussman JL. Complexes of alkylene-linked tacrine dimers with Torpedo californica acetylcholinesterase: Binding of Bis5- tacrine produces a dramatic rearrangement in the active-site gorge. J Med Chem 49, 5491-500 (2006).
+# Harel M, Hyatt JL, Brumshtein B, Morton CL, Wadkins RM, Silman I, Sussman JL, Potter PM. The 3D structure of the anticancer prodrug CPT-11 with Torpedo californica acetylcholinesterase rationalizes its inhibitory action on AChE and its hydrolysis by butyrylcholinesterase and carboxylesterase. Chem Biol Interact 157-158, 153-7 (2005).
+# Hyatt JL, Tsurkan L, Morton CL, Yoon KJ, Harel M, Brumshtein B, Silman I, Sussman JL, Wadkins RM, Potter PM. Inhibition of acetylcholinesterase by the anticancer prodrug CPT-11. Chem Biol Interact 157-158, 247-52 (2005).
+# Harel M, Hyatt JL, Brumshtein B, Morton CL, Yoon KJ, Wadkins RM, Silman I, Sussman JL, Potter PM. The crystal structure of the complex of the anticancer prodrug 7-ethyl-10-[4-(1-piperidino)-1-piperidino]-carbonyloxycamptothecin (CPT- 11) with Torpedo californica acetylcholinesterase provides a molecular explanation for its cholinergic action. Mol Pharmacol 67, 1874-81 (2005).
+# Harel M, Aharoni A, Gaidukov L, Brumshtein B, Khersonsky O, Meged R, Dvir H, Ravelli RB, McCarthy A, Toker L, Silman I, Sussman JL, Tawfik DS. Structure and evolution of the serum paraoxonase family of detoxifying and anti-atherosclerotic enzymes. Nat Struct Mol Biol 11, 412-9 (2004).
+# Adir, N., Rukhman, V., Brumshtein, B. & Anati, R. Preliminary X-ray crystallographic analysis of a soluble form of MntC, a periplasmic manganese- binding component of an ABC-type Mn transporter from Synechocystis sp. PCC 6803. Acta Crystallogr D Biol Crystallogr 58, 1476-8 (2002).