2r6d: Difference between revisions

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~~'''Unreleased structure'''~~

[[Image:2r6d.jpg|left|200px]]

The ~~entry~~ 2r6d ~~is ON HOLD~~ ~~until sometime in the future~~

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~~Authors: Bailey, S., Eliason, W.K., Steitz, T.A.~~

'''Crystal Form B1'''

~~Description: Crystal Form B1~~

==Overview==

The complex between the DnaB helicase and the DnaG primase unwinds duplex DNA at the eubacterial replication fork and synthesizes the Okazaki RNA primers. The crystal structures of hexameric DnaB and its complex with the helicase binding domain (HBD) of DnaG reveal that within the hexamer the two domains of DnaB pack with strikingly different symmetries to form a distinct two-layered ring structure. Each of three bound HBDs stabilizes the DnaB hexamer in a conformation that may increase its processivity. Three positive, conserved electrostatic patches on the N-terminal domain of DnaB may also serve as a binding site for DNA and thereby guide the DNA to a DnaG active site.

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jun 11 08:47:41 2008''

==About this Structure==

2R6D is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Geobacillus_stearothermophilus Geobacillus stearothermophilus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2R6D OCA].

==Reference==

Structure of hexameric DnaB helicase and its complex with a domain of DnaG primase., Bailey S, Eliason WK, Steitz TA, Science. 2007 Oct 19;318(5849):459-63. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17947583 17947583]

[[Category: Geobacillus stearothermophilus]]

[[Category: Single protein]]

[[Category: Bailey, S.]]

[[Category: Eliason, W K.]]

[[Category: Steitz, T A.]]

[[Category: Helicase]]

[[Category: Hexameric]]

[[Category: Replication dnab]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jun 11 10:44:39 2008''

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
+[[Image:2r6d.jpg|left|200px]]
-The entry 2r6d is ON HOLD  until sometime in the future
+<!--
+The line below this paragraph, containing "STRUCTURE_2r6d", creates the "Structure Box" on the page.
+You may change the PDB parameter (which sets the PDB file loaded into the applet)
+or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+or leave the SCENE parameter empty for the default display.
+-->
+{{STRUCTURE_2r6d|  PDB=2r6d  |  SCENE=  }}
-Authors: Bailey, S., Eliason, W.K., Steitz, T.A.
+'''Crystal Form B1'''
-Description: Crystal Form B1
+==Overview==
+The complex between the DnaB helicase and the DnaG primase unwinds duplex DNA at the eubacterial replication fork and synthesizes the Okazaki RNA primers. The crystal structures of hexameric DnaB and its complex with the helicase binding domain (HBD) of DnaG reveal that within the hexamer the two domains of DnaB pack with strikingly different symmetries to form a distinct two-layered ring structure. Each of three bound HBDs stabilizes the DnaB hexamer in a conformation that may increase its processivity. Three positive, conserved electrostatic patches on the N-terminal domain of DnaB may also serve as a binding site for DNA and thereby guide the DNA to a DnaG active site.
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jun 11 08:47:41 2008''
+==About this Structure==
+R6D is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Geobacillus_stearothermophilus Geobacillus stearothermophilus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2R6D OCA].
+==Reference==
+Structure of hexameric DnaB helicase and its complex with a domain of DnaG primase., Bailey S, Eliason WK, Steitz TA, Science. 2007 Oct 19;318(5849):459-63. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17947583 17947583]
+[[Category: Geobacillus stearothermophilus]]
+[[Category: Single protein]]
+[[Category: Bailey, S.]]
+[[Category: Eliason, W K.]]
+[[Category: Steitz, T A.]]
+[[Category: Helicase]]
+[[Category: Hexameric]]
+[[Category: Replication dnab]]
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jun 11 10:44:39 2008''