3cl3: Difference between revisions
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New page: '''Unreleased structure''' The entry 3cl3 is ON HOLD until Paper Publication Authors: Bagneris, C., Ageichik, A.V., Cronin, N., Boshoff, C., Waksman, G., Barrett, T. Description: Cryst... |
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{{STRUCTURE_3cl3| PDB=3cl3 | SCENE= }} | |||
'''Crystal Structure of a vFLIP-IKKgamma complex: Insights into viral activation of the IKK signalosome''' | |||
==Overview== | |||
Key to the pathogenicity of several viruses is activation of the canonical nuclear factor-kappaB (NF-kappaB) transcriptional pathway. Subversion of this tightly regulated mechanism is achieved through the production of host mimetic viral proteins that deregulate the transcription process. One such protein is ks-vFLIP (produced by the Kaposi's sarcoma herpes virus [KSHV]), which associates with IKKgamma, an essential component of the IKK complex or signalosome. This interaction renders the canonical NF-kappaB pathway constitutively active and has been linked to Kaposi's sarcoma and other malignancies. In order to elucidate the molecular basis underpinning ks-vFLIP-induced activation of the IKK signalosome, we have determined the crystal structure of a complex involving a fragment of IKKgamma bound to ks-vFLIP at 3.2 A. In addition to identifying and subsequently probing the ks-vFLIP-IKKgamma interface, we have also investigated the effects of a mutation implicated in the genetic disorder anhydrotic ectodermal dysplasia with immunodeficiency (EDA-ID). | |||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jun | ==About this Structure== | ||
3CL3 is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Human_herpesvirus_8 Human herpesvirus 8]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CL3 OCA]. | |||
==Reference== | |||
Crystal structure of a vFlip-IKKgamma complex: insights into viral activation of the IKK signalosome., Bagneris C, Ageichik AV, Cronin N, Wallace B, Collins M, Boshoff C, Waksman G, Barrett T, Mol Cell. 2008 Jun 6;30(5):620-31. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/18538660 18538660] | |||
[[Category: Homo sapiens]] | |||
[[Category: Human herpesvirus 8]] | |||
[[Category: Protein complex]] | |||
[[Category: Ageichik, A V.]] | |||
[[Category: Bagneris, C.]] | |||
[[Category: Barrett, T.]] | |||
[[Category: Boshoff, C.]] | |||
[[Category: Cronin, N.]] | |||
[[Category: Waksman, G.]] | |||
[[Category: Coiled coil]] | |||
[[Category: Coiled-coil]] | |||
[[Category: Cytoplasm]] | |||
[[Category: Death effector domain]] | |||
[[Category: Disease mutation]] | |||
[[Category: Ectodermal dysplasia]] | |||
[[Category: Host-virus interaction]] | |||
[[Category: Nucleus]] | |||
[[Category: Transcription]] | |||
[[Category: Transcription regulation]] | |||
[[Category: Viral protein/signaling protein complex]] | |||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jun 18 12:10:46 2008'' | |||
