3cl3: Difference between revisions

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[[Image:3cl3.jpg|left|200px]]
{{Seed}}
[[Image:3cl3.png|left|200px]]


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{{STRUCTURE_3cl3|  PDB=3cl3  |  SCENE=  }}  
{{STRUCTURE_3cl3|  PDB=3cl3  |  SCENE=  }}  


'''Crystal Structure of a vFLIP-IKKgamma complex: Insights into viral activation of the IKK signalosome'''
===Crystal Structure of a vFLIP-IKKgamma complex: Insights into viral activation of the IKK signalosome===




==Overview==
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Key to the pathogenicity of several viruses is activation of the canonical nuclear factor-kappaB (NF-kappaB) transcriptional pathway. Subversion of this tightly regulated mechanism is achieved through the production of host mimetic viral proteins that deregulate the transcription process. One such protein is ks-vFLIP (produced by the Kaposi's sarcoma herpes virus [KSHV]), which associates with IKKgamma, an essential component of the IKK complex or signalosome. This interaction renders the canonical NF-kappaB pathway constitutively active and has been linked to Kaposi's sarcoma and other malignancies. In order to elucidate the molecular basis underpinning ks-vFLIP-induced activation of the IKK signalosome, we have determined the crystal structure of a complex involving a fragment of IKKgamma bound to ks-vFLIP at 3.2 A. In addition to identifying and subsequently probing the ks-vFLIP-IKKgamma interface, we have also investigated the effects of a mutation implicated in the genetic disorder anhydrotic ectodermal dysplasia with immunodeficiency (EDA-ID).
The line below this paragraph, {{ABSTRACT_PUBMED_18538660}}, adds the Publication Abstract to the page
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{{ABSTRACT_PUBMED_18538660}}


==About this Structure==
==About this Structure==
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[[Category: Transcription regulation]]
[[Category: Transcription regulation]]
[[Category: Viral protein/signaling protein complex]]
[[Category: Viral protein/signaling protein complex]]
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