2h6a: Difference between revisions

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[[Image:2h6a.gif|left|200px]]
{{Seed}}
[[Image:2h6a.png|left|200px]]


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{{STRUCTURE_2h6a|  PDB=2h6a  |  SCENE=  }}  
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'''Crystal structure of the zinc-beta-lactamase L1 from Stenotrophomonas maltophilia (mono zinc form)'''
===Crystal structure of the zinc-beta-lactamase L1 from Stenotrophomonas maltophilia (mono zinc form)===




==Overview==
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One mechanism by which bacteria can escape the action of beta-lactam antibiotics is the production of metallo-beta-lactamases. Inhibition of these enzymes should restore the action of these widely used antibiotics. The tetrameric enzyme L1 from Stenotrophomonas maltophilia was used as a model system to determine a series of high-resolution crystal structures of apo, mono and bi-metal substituted proteins as well as protein-inhibitor complexes. Unexpectedly, although the apo structure revealed only few significant structural differences from the holo structure, some inhibitors were shown to induce amino acid side-chain rotations in the tightly packed active site. Moreover, one inhibitor employs a new binding mode in order to interact with the di-zinc center. This structural information could prove essential in the process of elucidation of the mode of interaction between a putative lead compound and metallo-beta-lactamases, one of the main steps in structure-based drug design.
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{{ABSTRACT_PUBMED_17999929}}


==About this Structure==
==About this Structure==
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[[Category: Metallo]]
[[Category: Metallo]]
[[Category: Zn]]
[[Category: Zn]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jun 18 12:15:26 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 16:03:15 2008''

Revision as of 13:03, 28 July 2008

File:2h6a.png

Template:STRUCTURE 2h6a

Crystal structure of the zinc-beta-lactamase L1 from Stenotrophomonas maltophilia (mono zinc form)

Template:ABSTRACT PUBMED 17999929

About this Structure

2H6A is a Single protein structure of sequence from Stenotrophomonas maltophilia. Full crystallographic information is available from OCA.

Reference

Structural insights into the design of inhibitors for the L1 metallo-beta-lactamase from Stenotrophomonas maltophilia., Nauton L, Kahn R, Garau G, Hernandez JF, Dideberg O, J Mol Biol. 2008 Jan 4;375(1):257-69. Epub 2007 Oct 22. PMID:17999929

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