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| {{STRUCTURE_2zl3| PDB=2zl3 | SCENE= }} | | {{STRUCTURE_2zl3| PDB=2zl3 | SCENE= }} |
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| '''Crystal structure of H.pylori ClpP S99A'''
| | ===Crystal structure of H.pylori ClpP S99A=== |
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| ==Overview==
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| ClpP and its ATPase compartment, ClpX or ClpA, remove misfolded proteins in cells and are of utmost importance in protein quality control. The ring hexamers of ClpA or ClpX recognize, unfold, and translocate target substrates into the degradation chamber of the double-ring tetradecamer of ClpP. The overall reaction scheme catalyzed by ClpXP or ClpAP has been proposed; however, the molecular mechanisms associated with substrate recognition and degradation have not yet been clarified in detail. To investigate these mechanisms, we determined the crystal structures of ClpP from Helicobacter pylori in complex with product peptides bound to the active site as well as in the apo state. In the complex structure, the peptides are zipped with two antiparallel strands of ClpP and point to the adjacent active site, thus providing structural explanations for the broad substrate specificity, the product inhibition and the processive degradation of substrates in the chamber. The structures also suggest that substrate binding causes local conformational changes around the active site that ultimately induce the active conformation of ClpP.
| | The line below this paragraph, {{ABSTRACT_PUBMED_18468623}}, adds the Publication Abstract to the page |
| | (as it appears on PubMed at http://www.pubmed.gov), where 18468623 is the PubMed ID number. |
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| | {{ABSTRACT_PUBMED_18468623}} |
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| ==About this Structure== | | ==About this Structure== |
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| [[Category: S99a]] | | [[Category: S99a]] |
| [[Category: Serine protease]] | | [[Category: Serine protease]] |
| ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jun 18 12:19:46 2008'' | | |
| | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 10:07:32 2008'' |
