1cmc: Difference between revisions

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[[Image:1cmc.gif|left|200px]]<br /><applet load="1cmc" size="~~450~~" color="white" frame="true" align="right" spinBox="true"

[[Image:1cmc.gif|left|200px]]<br /><applet load="1cmc" size="350" color="white" frame="true" align="right" spinBox="true"

caption="1cmc, resolution 1.8Å" />

'''THREE DIMENSIONAL CRYSTAL STRUCTURES OF E. COLI MET REPRESSOR WITH AND WITHOUT COREPRESSOR'''<br />

==Overview==

The three-dimensional crystal structure of met repressor, in the presence, or absence of bound corepressor (S-adenosylmethionine), shows a dimer of, intertwined monomers, which do not have the helix-turn-helix motif, characteristic of other bacterial repressor and activator structures. We, propose that the interaction of met repressor with DNA occurs through, either a pair of symmetry-related alpha-helices or a pair of beta-strands, and suggest a model for binding of several dimers to met operator regions.

The three-dimensional crystal structure of met repressor, in the presence or absence of bound corepressor (S-adenosylmethionine), shows a dimer of intertwined monomers, which do not have the helix-turn-helix motif characteristic of other bacterial repressor and activator structures. We propose that the interaction of met repressor with DNA occurs through either a pair of symmetry-related alpha-helices or a pair of beta-strands, and suggest a model for binding of several dimers to met operator regions.

==About this Structure==

1CMC is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli] with MG and SAM as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://~~ispc~~.weizmann.ac.il/oca-bin/ocashort?id=1CMC OCA].

1CMC is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli] with <scene name='pdbligand=MG:'>MG</scene> and <scene name='pdbligand=SAM:'>SAM</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CMC OCA].

==Reference==

Line 13:

[[Category: Escherichia coli]]

[[Category: Single protein]]

[[Category: Phillips, S.E.V.]]

[[Category: Phillips, S E.V.]]

[[Category: Somers, W.S.]]

[[Category: Somers, W S.]]

[[Category: MG]]

[[Category: SAM]]

[[Category: dna-binding regulatory protein]]

''Page seeded by [http://~~ispc~~.weizmann.ac.il/oca OCA ] on ~~Tue Nov 20~~ 12:34:~~47 2007~~''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 12:07:30 2008''

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@@ Line 1: / Line 1: @@
-[[Image:1cmc.gif|left|200px]]<br /><applet load="1cmc" size="450" color="white" frame="true" align="right" spinBox="true"
+[[Image:1cmc.gif|left|200px]]<br /><applet load="1cmc" size="350" color="white" frame="true" align="right" spinBox="true"
 caption="1cmc, resolution 1.8&Aring;" />
 '''THREE DIMENSIONAL CRYSTAL STRUCTURES OF E. COLI MET REPRESSOR WITH AND WITHOUT COREPRESSOR'''<br />
 ==Overview==
-The three-dimensional crystal structure of met repressor, in the presence, or absence of bound corepressor (S-adenosylmethionine), shows a dimer of, intertwined monomers, which do not have the helix-turn-helix motif, characteristic of other bacterial repressor and activator structures. We, propose that the interaction of met repressor with DNA occurs through, either a pair of symmetry-related alpha-helices or a pair of beta-strands, and suggest a model for binding of several dimers to met operator regions.
+The three-dimensional crystal structure of met repressor, in the presence or absence of bound corepressor (S-adenosylmethionine), shows a dimer of intertwined monomers, which do not have the helix-turn-helix motif characteristic of other bacterial repressor and activator structures. We propose that the interaction of met repressor with DNA occurs through either a pair of symmetry-related alpha-helices or a pair of beta-strands, and suggest a model for binding of several dimers to met operator regions.
 ==About this Structure==
-CMC is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli] with MG and SAM as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1CMC OCA].
+CMC is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli] with <scene name='pdbligand=MG:'>MG</scene> and <scene name='pdbligand=SAM:'>SAM</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CMC OCA].
 ==Reference==
@@ Line 13: / Line 13: @@
 [[Category: Escherichia coli]]
 [[Category: Single protein]]
-[[Category: Phillips, S.E.V.]]
+[[Category: Phillips, S E.V.]]
-[[Category: Somers, W.S.]]
+[[Category: Somers, W S.]]
 [[Category: MG]]
 [[Category: SAM]]
 [[Category: dna-binding regulatory protein]]
-''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Nov 20 12:34:47 2007''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 12:07:30 2008''