1csn: Difference between revisions

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[[Image:1csn.gif|left|200px]]<br /><applet load="1csn" size="~~450~~" color="white" frame="true" align="right" spinBox="true"

[[Image:1csn.gif|left|200px]]<br /><applet load="1csn" size="350" color="white" frame="true" align="right" spinBox="true"

caption="1csn, resolution 2.0Å" />

'''BINARY COMPLEX OF CASEIN KINASE-1 WITH MGATP'''<br />

==Overview==

The structure of a truncated variant of casein kinase-1 from, Schizosaccharomyces pombe, has been determined in complex with MgATP at, 2.0 A resolution. The model resembles the 'closed', ATP-bound, conformations of the cyclin-dependent kinase 2 and the cAMP-dependent, protein kinase, with clear differences in the structure of surface loops, that impart unique features to casein kinase-1. The structure is of, unphosphorylated, active conformation of casein kinase-1 and the, peptide-binding site is fully accessible to substrate.

The structure of a truncated variant of casein kinase-1 from Schizosaccharomyces pombe, has been determined in complex with MgATP at 2.0 A resolution. The model resembles the 'closed', ATP-bound conformations of the cyclin-dependent kinase 2 and the cAMP-dependent protein kinase, with clear differences in the structure of surface loops that impart unique features to casein kinase-1. The structure is of unphosphorylated, active conformation of casein kinase-1 and the peptide-binding site is fully accessible to substrate.

==About this Structure==

1CSN is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Schizosaccharomyces_pombe Schizosaccharomyces pombe] with MG, SO4 and ATP as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://~~ispc~~.weizmann.ac.il/oca-bin/ocashort?id=1CSN OCA].

1CSN is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Schizosaccharomyces_pombe Schizosaccharomyces pombe] with <scene name='pdbligand=MG:'>MG</scene>, <scene name='pdbligand=SO4:'>SO4</scene> and <scene name='pdbligand=ATP:'>ATP</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CSN OCA].

==Reference==

Line 14:

[[Category: Single protein]]

[[Category: Cheng, X.]]

[[Category: Xu, R.M.]]

[[Category: Xu, R M.]]

[[Category: ATP]]

[[Category: MG]]

Line 20:

[[Category: phosphotransferase]]

''Page seeded by [http://~~ispc~~.weizmann.ac.il/oca OCA ] on ~~Tue Nov 20~~ 12:43:~~38 2007~~''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 12:09:18 2008''

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@@ Line 1: / Line 1: @@
-[[Image:1csn.gif|left|200px]]<br /><applet load="1csn" size="450" color="white" frame="true" align="right" spinBox="true"
+[[Image:1csn.gif|left|200px]]<br /><applet load="1csn" size="350" color="white" frame="true" align="right" spinBox="true"
 caption="1csn, resolution 2.0&Aring;" />
 '''BINARY COMPLEX OF CASEIN KINASE-1 WITH MGATP'''<br />
 ==Overview==
-The structure of a truncated variant of casein kinase-1 from, Schizosaccharomyces pombe, has been determined in complex with MgATP at, 2.0 A resolution. The model resembles the 'closed', ATP-bound, conformations of the cyclin-dependent kinase 2 and the cAMP-dependent, protein kinase, with clear differences in the structure of surface loops, that impart unique features to casein kinase-1. The structure is of, unphosphorylated, active conformation of casein kinase-1 and the, peptide-binding site is fully accessible to substrate.
+The structure of a truncated variant of casein kinase-1 from Schizosaccharomyces pombe, has been determined in complex with MgATP at 2.0 A resolution. The model resembles the 'closed', ATP-bound conformations of the cyclin-dependent kinase 2 and the cAMP-dependent protein kinase, with clear differences in the structure of surface loops that impart unique features to casein kinase-1. The structure is of unphosphorylated, active conformation of casein kinase-1 and the peptide-binding site is fully accessible to substrate.
 ==About this Structure==
-CSN is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Schizosaccharomyces_pombe Schizosaccharomyces pombe] with MG, SO4 and ATP as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1CSN OCA].
+CSN is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Schizosaccharomyces_pombe Schizosaccharomyces pombe] with <scene name='pdbligand=MG:'>MG</scene>, <scene name='pdbligand=SO4:'>SO4</scene> and <scene name='pdbligand=ATP:'>ATP</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CSN OCA].
 ==Reference==
@@ Line 14: / Line 14: @@
 [[Category: Single protein]]
 [[Category: Cheng, X.]]
-[[Category: Xu, R.M.]]
+[[Category: Xu, R M.]]
 [[Category: ATP]]
 [[Category: MG]]
@@ Line 20: / Line 20: @@
 [[Category: phosphotransferase]]
-''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Nov 20 12:43:38 2007''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 12:09:18 2008''