1ctl: Difference between revisions

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[[Image:1ctl.gif|left|200px]]<br /><applet load="1ctl" size="~~450~~" color="white" frame="true" align="right" spinBox="true"

[[Image:1ctl.gif|left|200px]]<br /><applet load="1ctl" size="350" color="white" frame="true" align="right" spinBox="true"

caption="1ctl" />

'''STRUCTURE OF THE CARBOXY-TERMINAL LIM DOMAIN FROM THE CYSTEINE RICH PROTEIN CRP'''<br />

==Overview==

The three dimensional solution structure of the carboxy terminal LIM, domain of the avian Cysteine Rich Protein (CRP) has been determined by, nuclear magnetic resonance spectroscopy. The domain contains two zinc, atoms bound independently in CCHC (C = Cys, H = His) and CCCC modules., Both modules contain two orthogonally-arranged antiparallel beta-sheets, and the CCCC module contains an alpha-helix at its C terminus. The modules, pack due to hydrophobic interactions forming a novel global fold. The, structure of the C-terminal CCCC module is essentially identical to that, observed for the DNA-interactive CCCC modules of the GATA-1 and steroid, hormone receptor DNA binding domains, raising the possibility that the LIM, motif may have a DNA binding function.

The three dimensional solution structure of the carboxy terminal LIM domain of the avian Cysteine Rich Protein (CRP) has been determined by nuclear magnetic resonance spectroscopy. The domain contains two zinc atoms bound independently in CCHC (C = Cys, H = His) and CCCC modules. Both modules contain two orthogonally-arranged antiparallel beta-sheets, and the CCCC module contains an alpha-helix at its C terminus. The modules pack due to hydrophobic interactions forming a novel global fold. The structure of the C-terminal CCCC module is essentially identical to that observed for the DNA-interactive CCCC modules of the GATA-1 and steroid hormone receptor DNA binding domains, raising the possibility that the LIM motif may have a DNA binding function.

==About this Structure==

1CTL is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus] with ZN as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://~~ispc~~.weizmann.ac.il/oca-bin/ocashort?id=1CTL OCA].

1CTL is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus] with <scene name='pdbligand=ZN:'>ZN</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CTL OCA].

==Reference==

Line 13:

[[Category: Gallus gallus]]

[[Category: Single protein]]

[[Category: Beckerle, M.C.]]

[[Category: Beckerle, M C.]]

[[Category: Louis, H.A.]]

[[Category: Louis, H A.]]

[[Category: Michelsen, J.W.]]

[[Category: Michelsen, J W.]]

[[Category: Miles, C.]]

[[Category: Perez-Alvarado, G.C.]]

[[Category: Perez-Alvarado, G C.]]

[[Category: Summers, M.F.]]

[[Category: Summers, M F.]]

[[Category: Winge, D.R.]]

[[Category: Winge, D R.]]

[[Category: ZN]]

[[Category: lim domain containing proteins]]

''Page seeded by [http://~~ispc~~.weizmann.ac.il/oca OCA ] on ~~Tue Nov 20~~ 12:44:~~56 2007~~''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 12:09:33 2008''

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@@ Line 1: / Line 1: @@
-[[Image:1ctl.gif|left|200px]]<br /><applet load="1ctl" size="450" color="white" frame="true" align="right" spinBox="true"
+[[Image:1ctl.gif|left|200px]]<br /><applet load="1ctl" size="350" color="white" frame="true" align="right" spinBox="true"
 caption="1ctl" />
 '''STRUCTURE OF THE CARBOXY-TERMINAL LIM DOMAIN FROM THE CYSTEINE RICH PROTEIN CRP'''<br />
 ==Overview==
-The three dimensional solution structure of the carboxy terminal LIM, domain of the avian Cysteine Rich Protein (CRP) has been determined by, nuclear magnetic resonance spectroscopy. The domain contains two zinc, atoms bound independently in CCHC (C = Cys, H = His) and CCCC modules., Both modules contain two orthogonally-arranged antiparallel beta-sheets, and the CCCC module contains an alpha-helix at its C terminus. The modules, pack due to hydrophobic interactions forming a novel global fold. The, structure of the C-terminal CCCC module is essentially identical to that, observed for the DNA-interactive CCCC modules of the GATA-1 and steroid, hormone receptor DNA binding domains, raising the possibility that the LIM, motif may have a DNA binding function.
+The three dimensional solution structure of the carboxy terminal LIM domain of the avian Cysteine Rich Protein (CRP) has been determined by nuclear magnetic resonance spectroscopy. The domain contains two zinc atoms bound independently in CCHC (C = Cys, H = His) and CCCC modules. Both modules contain two orthogonally-arranged antiparallel beta-sheets, and the CCCC module contains an alpha-helix at its C terminus. The modules pack due to hydrophobic interactions forming a novel global fold. The structure of the C-terminal CCCC module is essentially identical to that observed for the DNA-interactive CCCC modules of the GATA-1 and steroid hormone receptor DNA binding domains, raising the possibility that the LIM motif may have a DNA binding function.
 ==About this Structure==
-CTL is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus] with ZN as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1CTL OCA].
+CTL is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus] with <scene name='pdbligand=ZN:'>ZN</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CTL OCA].
 ==Reference==
@@ Line 13: / Line 13: @@
 [[Category: Gallus gallus]]
 [[Category: Single protein]]
-[[Category: Beckerle, M.C.]]
+[[Category: Beckerle, M C.]]
-[[Category: Louis, H.A.]]
+[[Category: Louis, H A.]]
-[[Category: Michelsen, J.W.]]
+[[Category: Michelsen, J W.]]
 [[Category: Miles, C.]]
-[[Category: Perez-Alvarado, G.C.]]
+[[Category: Perez-Alvarado, G C.]]
-[[Category: Summers, M.F.]]
+[[Category: Summers, M F.]]
-[[Category: Winge, D.R.]]
+[[Category: Winge, D R.]]
 [[Category: ZN]]
 [[Category: lim domain containing proteins]]
-''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Nov 20 12:44:56 2007''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 12:09:33 2008''