1d0b: Difference between revisions

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[[Image:1d0b.jpg|left|200px]]<br /><applet load="1d0b" size="~~450~~" color="white" frame="true" align="right" spinBox="true"

[[Image:1d0b.jpg|left|200px]]<br /><applet load="1d0b" size="350" color="white" frame="true" align="right" spinBox="true"

caption="1d0b, resolution 1.86Å" />

'''INTERNALIN B LEUCINE RICH REPEAT DOMAIN'''<br />

==Overview==

The L. monocytogenes protein lnlB activates phosphoinositide 3-kinase and, induces phagocytosis in several mammalian cell types. The 1.86 A, resolution X-ray crystal structure of the leucine-rich repeat domain of, lnlB that is both necessary and sufficient to induce phagocytosis is, presented here. The structure supports a crucial role for calcium in host, cell invasion by L. monocytogenes and supplies a rationale for its, function. Calciums are bound to the protein in an unusually exposed manner, that suggests that the metals may act as a bridge between lnlB and, mammalian cell surface receptors. The structure also identifies surfaces, on the curved and elongated molecule that may constitute additional, interaction sites in forming a bacterial-mammalian signaling complex.

The L. monocytogenes protein lnlB activates phosphoinositide 3-kinase and induces phagocytosis in several mammalian cell types. The 1.86 A resolution X-ray crystal structure of the leucine-rich repeat domain of lnlB that is both necessary and sufficient to induce phagocytosis is presented here. The structure supports a crucial role for calcium in host cell invasion by L. monocytogenes and supplies a rationale for its function. Calciums are bound to the protein in an unusually exposed manner that suggests that the metals may act as a bridge between lnlB and mammalian cell surface receptors. The structure also identifies surfaces on the curved and elongated molecule that may constitute additional interaction sites in forming a bacterial-mammalian signaling complex.

==About this Structure==

1D0B is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Listeria_monocytogenes Listeria monocytogenes] with CA as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://~~ispc~~.weizmann.ac.il/oca-bin/ocashort?id=1D0B OCA].

1D0B is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Listeria_monocytogenes Listeria monocytogenes] with <scene name='pdbligand=CA:'>CA</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1D0B OCA].

==Reference==

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[[Category: leucine rich repeat]]

''Page seeded by [http://~~ispc~~.weizmann.ac.il/oca OCA ] on ~~Tue Nov 20~~ 12:54:~~12 2007~~''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 12:11:34 2008''

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@@ Line 1: / Line 1: @@
-[[Image:1d0b.jpg|left|200px]]<br /><applet load="1d0b" size="450" color="white" frame="true" align="right" spinBox="true"
+[[Image:1d0b.jpg|left|200px]]<br /><applet load="1d0b" size="350" color="white" frame="true" align="right" spinBox="true"
 caption="1d0b, resolution 1.86&Aring;" />
 '''INTERNALIN B LEUCINE RICH REPEAT DOMAIN'''<br />
 ==Overview==
-The L. monocytogenes protein lnlB activates phosphoinositide 3-kinase and, induces phagocytosis in several mammalian cell types. The 1.86 A, resolution X-ray crystal structure of the leucine-rich repeat domain of, lnlB that is both necessary and sufficient to induce phagocytosis is, presented here. The structure supports a crucial role for calcium in host, cell invasion by L. monocytogenes and supplies a rationale for its, function. Calciums are bound to the protein in an unusually exposed manner, that suggests that the metals may act as a bridge between lnlB and, mammalian cell surface receptors. The structure also identifies surfaces, on the curved and elongated molecule that may constitute additional, interaction sites in forming a bacterial-mammalian signaling complex.
+The L. monocytogenes protein lnlB activates phosphoinositide 3-kinase and induces phagocytosis in several mammalian cell types. The 1.86 A resolution X-ray crystal structure of the leucine-rich repeat domain of lnlB that is both necessary and sufficient to induce phagocytosis is presented here. The structure supports a crucial role for calcium in host cell invasion by L. monocytogenes and supplies a rationale for its function. Calciums are bound to the protein in an unusually exposed manner that suggests that the metals may act as a bridge between lnlB and mammalian cell surface receptors. The structure also identifies surfaces on the curved and elongated molecule that may constitute additional interaction sites in forming a bacterial-mammalian signaling complex.
 ==About this Structure==
-D0B is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Listeria_monocytogenes Listeria monocytogenes] with CA as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1D0B OCA].
+D0B is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Listeria_monocytogenes Listeria monocytogenes] with <scene name='pdbligand=CA:'>CA</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1D0B OCA].
 ==Reference==
@@ Line 21: / Line 21: @@
 [[Category: leucine rich repeat]]
-''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Nov 20 12:54:12 2007''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 12:11:34 2008''