1d0h: Difference between revisions

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[[Image:1d0h.gif|left|200px]]<br /><applet load="1d0h" size="~~450~~" color="white" frame="true" align="right" spinBox="true"

[[Image:1d0h.gif|left|200px]]<br /><applet load="1d0h" size="350" color="white" frame="true" align="right" spinBox="true"

caption="1d0h, resolution 2.10Å" />

'''THE HC FRAGMENT OF TETANUS TOXIN COMPLEXED WITH N-ACETYL-GALACTOSAMINE'''<br />

==Overview==

The entry of tetanus neurotoxin into neuronal cells proceeds through the, initial binding of the toxin to gangliosides on the cell surface. The, carboxyl-terminal fragment of the heavy chain of tetanus neurotoxin, contains the ganglioside-binding site, which has not yet been fully, characterized. The crystal structures of native H(C) and of H(C) soaked, with carbohydrates reveal a number of binding sites and provide insight, into the possible mode of ganglioside binding.

The entry of tetanus neurotoxin into neuronal cells proceeds through the initial binding of the toxin to gangliosides on the cell surface. The carboxyl-terminal fragment of the heavy chain of tetanus neurotoxin contains the ganglioside-binding site, which has not yet been fully characterized. The crystal structures of native H(C) and of H(C) soaked with carbohydrates reveal a number of binding sites and provide insight into the possible mode of ganglioside binding.

==About this Structure==

1D0H is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Clostridium_tetani Clostridium tetani] with A2G and SO4 as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://~~ispc~~.weizmann.ac.il/oca-bin/ocashort?id=1D0H OCA].

1D0H is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Clostridium_tetani Clostridium tetani] with <scene name='pdbligand=A2G:'>A2G</scene> and <scene name='pdbligand=SO4:'>SO4</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1D0H OCA].

==Reference==

Line 14:

[[Category: Single protein]]

[[Category: Black, I.]]

[[Category: Charles, I.G.]]

[[Category: Charles, I G.]]

[[Category: Emsley, P.]]

[[Category: Fairweather, N.F.]]

[[Category: Fairweather, N F.]]

[[Category: Fotinou, C.]]

[[Category: Hewitt, E.]]

[[Category: Isaacs, N.W.]]

[[Category: Isaacs, N W.]]

[[Category: Watts, C.]]

[[Category: A2G]]

Line 27:

[[Category: toxin]]

''Page seeded by [http://~~ispc~~.weizmann.ac.il/oca OCA ] on ~~Tue Nov 20~~ 12:54:~~30 2007~~''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 12:11:36 2008''

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@@ Line 1: / Line 1: @@
-[[Image:1d0h.gif|left|200px]]<br /><applet load="1d0h" size="450" color="white" frame="true" align="right" spinBox="true"
+[[Image:1d0h.gif|left|200px]]<br /><applet load="1d0h" size="350" color="white" frame="true" align="right" spinBox="true"
 caption="1d0h, resolution 2.10&Aring;" />
 '''THE HC FRAGMENT OF TETANUS TOXIN COMPLEXED WITH N-ACETYL-GALACTOSAMINE'''<br />
 ==Overview==
-The entry of tetanus neurotoxin into neuronal cells proceeds through the, initial binding of the toxin to gangliosides on the cell surface. The, carboxyl-terminal fragment of the heavy chain of tetanus neurotoxin, contains the ganglioside-binding site, which has not yet been fully, characterized. The crystal structures of native H(C) and of H(C) soaked, with carbohydrates reveal a number of binding sites and provide insight, into the possible mode of ganglioside binding.
+The entry of tetanus neurotoxin into neuronal cells proceeds through the initial binding of the toxin to gangliosides on the cell surface. The carboxyl-terminal fragment of the heavy chain of tetanus neurotoxin contains the ganglioside-binding site, which has not yet been fully characterized. The crystal structures of native H(C) and of H(C) soaked with carbohydrates reveal a number of binding sites and provide insight into the possible mode of ganglioside binding.
 ==About this Structure==
-D0H is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Clostridium_tetani Clostridium tetani] with A2G and SO4 as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1D0H OCA].
+D0H is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Clostridium_tetani Clostridium tetani] with <scene name='pdbligand=A2G:'>A2G</scene> and <scene name='pdbligand=SO4:'>SO4</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1D0H OCA].
 ==Reference==
@@ Line 14: / Line 14: @@
 [[Category: Single protein]]
 [[Category: Black, I.]]
-[[Category: Charles, I.G.]]
+[[Category: Charles, I G.]]
 [[Category: Emsley, P.]]
-[[Category: Fairweather, N.F.]]
+[[Category: Fairweather, N F.]]
 [[Category: Fotinou, C.]]
 [[Category: Hewitt, E.]]
-[[Category: Isaacs, N.W.]]
+[[Category: Isaacs, N W.]]
 [[Category: Watts, C.]]
 [[Category: A2G]]
@@ Line 27: / Line 27: @@
 [[Category: toxin]]
-''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Nov 20 12:54:30 2007''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 12:11:36 2008''